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Review
. 2013 Aug;11(8):551-60.
doi: 10.1038/nrmicro3072.

The non-canonical roles of clathrin and actin in pathogen internalization, egress and spread

Ashley C Humphries  1 , Michael Way
Affiliations
Review

The non-canonical roles of clathrin and actin in pathogen internalization, egress and spread

Ashley C Humphries et al. Nat Rev Microbiol. 2013 Aug.

Abstract

The role of clathrin in pathogen entry has received much attention and has highlighted the adaptability of clathrin during internalization. Recent studies have now uncovered additional roles for clathrin and have put the spotlight on its role in pathogen spread. Here, we discuss the manipulation of clathrin by pathogens, with specific attention to the processes that occur at the plasma membrane. In the majority of cases, both clathrin and the actin cytoskeleton are hijacked, so we also examine the interplay between these two systems and their role during pathogen internalization, egress and spread.

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References

    1. Nat Cell Biol. 2002 May;4(5):394-8 - PubMed
    1. PLoS Pathog. 2010 Sep 30;6(9):e1001127 - PubMed
    1. J Virol. 2003 Aug;77(16):9008-19 - PubMed
    1. Curr Biol. 2013 Jun 3;23(11):999-1006 - PubMed
    1. Dev Cell. 2011 Jul 19;21(1):77-91 - PubMed

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