Metabolites from intestinal microbes shape Treg

doi:10.1038/cr.2013.125

Comment

. 2013 Dec;23(12):1339-40.

doi: 10.1038/cr.2013.125. Epub 2013 Sep 10.

Metabolites from intestinal microbes shape Treg

Markus B Geuking¹, Kathy D McCoy, Andrew J Macpherson

Affiliations

PMID: 24018374
PMCID: PMC3847568
DOI: 10.1038/cr.2013.125

Comment

Metabolites from intestinal microbes shape Treg

Markus B Geuking et al. Cell Res. 2013 Dec.

. 2013 Dec;23(12):1339-40.

doi: 10.1038/cr.2013.125. Epub 2013 Sep 10.

Authors

Markus B Geuking¹, Kathy D McCoy, Andrew J Macpherson

Affiliation

¹ University of Bern, Maurice Müller Laboratories (DKF), University Clinic for Visceral Surgery and Medicine, Murtenstrasse 35, CH-3010 Bern, Switzerland.

PMID: 24018374
PMCID: PMC3847568
DOI: 10.1038/cr.2013.125

Abstract

Intestinal bacterial metabolites are an important communication tool between the host immune system and the commensal microbiota to establish mutualism. In a recent paper published in Science, Wendy Garrett and her colleagues report an exciting role of the three most abundant microbial-derived short-chain fatty acids (SCFA), acetic acid, propionic acid and butyric acid, in colonic regulatory T cell (cTreg) homeostasis.

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Figures

**Figure 1**
Bacterial metabolites that reach systemic sites likely modulate adaptive or innate immune cell function at systemic sites. This may eventually rationalize the observed correlation of microbiota composition and susceptibility to systemic immune-mediated disorders such as autoimmune or allergic diseases.

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Comment on

The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis.
Smith PM, Howitt MR, Panikov N, Michaud M, Gallini CA, Bohlooly-Y M, Glickman JN, Garrett WS. Smith PM, et al. Science. 2013 Aug 2;341(6145):569-73. doi: 10.1126/science.1241165. Epub 2013 Jul 4. Science. 2013. PMID: 23828891 Free PMC article.

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References

1. Round JL, Mazmanian SK. Proc Natl Acad Sci USA. 2010. pp. 12204–12209. - PMC - PubMed
1. Geuking MB, Cahenzli J, Lawson MA, et al. Immunity. 2011. pp. 794–806. - PubMed
1. Atarashi K, Tanoue T, Shima T, et al. Science. 2011. pp. 337–341. - PMC - PubMed
1. Smith PM, Howitt MR, Panikov N, et al. Science. 2013. pp. 569–573. - PMC - PubMed
1. Roediger WE. Gastroenterology. 1982. pp. 424–429. - PubMed

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[1] Round JL, Mazmanian SK. Proc Natl Acad Sci USA. 2010. pp. 12204–12209. - PMC - PubMed

[2] Round JL, Mazmanian SK. Proc Natl Acad Sci USA. 2010. pp. 12204–12209. - PMC - PubMed

[3] Geuking MB, Cahenzli J, Lawson MA, et al. Immunity. 2011. pp. 794–806. - PubMed

[4] Geuking MB, Cahenzli J, Lawson MA, et al. Immunity. 2011. pp. 794–806. - PubMed

[5] Atarashi K, Tanoue T, Shima T, et al. Science. 2011. pp. 337–341. - PMC - PubMed

[6] Atarashi K, Tanoue T, Shima T, et al. Science. 2011. pp. 337–341. - PMC - PubMed

[7] Smith PM, Howitt MR, Panikov N, et al. Science. 2013. pp. 569–573. - PMC - PubMed

[8] Smith PM, Howitt MR, Panikov N, et al. Science. 2013. pp. 569–573. - PMC - PubMed

[9] Roediger WE. Gastroenterology. 1982. pp. 424–429. - PubMed

[10] Roediger WE. Gastroenterology. 1982. pp. 424–429. - PubMed

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Metabolites from intestinal microbes shape Treg

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Metabolites from intestinal microbes shape Treg

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