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Comment
. 2013 Sep 3:2:e01387.
doi: 10.7554/eLife.01387.

Making the most of methylation

Michiel Vermeulen  1
Affiliations
Comment

Making the most of methylation

Michiel Vermeulen. Elife. .

Abstract

A high-throughput screening approach based on a protein microarray reveals that many human transcription factors interact specifically with methylated promoter sequences.

Keywords: DNA methylation; Human; epigenetics; protein microarray; protein-DNA interactions; transcription factors; transcription regulation.

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Conflict of interest statement

Competing interests:The author declares that no competing interests exist.

Figures

Figure 1.
Figure 1.
Some human transcription factors can bind to both methylated and non-methylated DNA sequences. Hu et al. examined the ability of 17 human transcription factors to bind to 150 different DNA motifs containing methylated or non-methylated CpG islands. Each row represents one transcription factor. For each motif, some transcription factors bound only to the methylated version (red), some to only the non-methylated version (blue); some to both methylated and non-methylated versions (green), and some to neither (grey). From Figure 2a in Hu et al., 2013.
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