Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2013 Dec;23(6 Pt B):533-42.
doi: 10.1016/j.semcancer.2013.08.009. Epub 2013 Sep 4.

β-Adrenergic system, a backstage manipulator regulating tumour progression and drug target in cancer therapy

Jing Tang  1 , Zhijie Li, Lan Lu, Chi Hin Cho
Affiliations
Free article
Review

β-Adrenergic system, a backstage manipulator regulating tumour progression and drug target in cancer therapy

Jing Tang et al. Semin Cancer Biol. 2013 Dec.
Free article

Abstract

β-Adrenoceptors are broadly distributed in various tissues of the body. Stress hormones regulate a panel of important physiological functions and disease states including cancer. Nicotine and its derivatives could stimulate the release of stress hormones from cancer cells, leading to the promotion of cancer development. β-Blockers have been widely used to control hypertension for decades. Recently, these agents could have significant implications in cancer therapy through blockade of adrenoceptors in tumour tissues. In this review, we summarize recent advancements about the influence of stress hormones, nicotine and β-adrenoceptors on cancer cell proliferation, apoptosis, invasion and metastasis, and also tumour vasculature normalization. Relevant signal pathways and potential value of β-blockers in the treatment of cancer are also discussed in this review.

Keywords: 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone; AC; AP1; Angiogenesis; BAD; BCL2-associated death protein; CREB; DR; EC; EPAC; FAK; GABA; GROα; HIF-1α; HRG; IL-6; MAPK; MMP; NF-κB; NNK; Nicotine; PDGF; PI3K; PKA; PVC; PlGF; STAT3; Stress hormones; TAM; TGF-β; Tumour progression; VEGF; activator protein 1; adenylyl cyclase; cAMP; cAMP response element binding protein; cyclic AMP; dopamine receptor; endothelial cells; exchange protein activated by adenylyl cyclase; focal adhesion kinase; growth-regulated oncogene alpha; histidine-rich glycoprotein; hypoxia-inducible factor-1; interleukin-6; matrix metalloproteinase; mitogen-activated protein kinase; nAChR; nicotinic acetylcholine receptors; nuclear factor-κB; p70S6 kinase; p70S6K; perivascular cell; phosphoinositide 3-kinase; placenta-derived growth factor; platelet-derived growth factor; protein kinase A; signal transducer and activator of transcription-3; transforming growth factor β; tumor associated macrophages; vascular endothelial growth factor; β-Adrenergic system; β-Adrenoceptors; β-Blockers; γ-aminobutyric acid.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

Substances