ADAR-mediated RNA editing in non-coding RNA sequences
- PMID: 24008387
- DOI: 10.1007/s11427-013-4546-5
ADAR-mediated RNA editing in non-coding RNA sequences
Abstract
Adenosine to inosine (A-to-I) RNA editing is the most abundant editing event in animals. It converts adenosine to inosine in double-stranded RNA regions through the action of the adenosine deaminase acting on RNA (ADAR) proteins. Editing of pre-mRNA coding regions can alter the protein codon and increase functional diversity. However, most of the A-to-I editing sites occur in the non-coding regions of pre-mRNA or mRNA and non-coding RNAs. Untranslated regions (UTRs) and introns are located in pre-mRNA non-coding regions, thus A-to-I editing can influence gene expression by nuclear retention, degradation, alternative splicing, and translation regulation. Non-coding RNAs such as microRNA (miRNA), small interfering RNA (siRNA) and long non-coding RNA (lncRNA) are related to pre-mRNA splicing, translation, and gene regulation. A-to-I editing could therefore affect the stability, biogenesis, and target recognition of non-coding RNAs. Finally, it may influence the function of non-coding RNAs, resulting in regulation of gene expression. This review focuses on the function of ADAR-mediated RNA editing on mRNA non-coding regions (UTRs and introns) and non-coding RNAs (miRNA, siRNA, and lncRNA).
Similar articles
-
Noncoding regions of C. elegans mRNA undergo selective adenosine to inosine deamination and contain a small number of editing sites per transcript.RNA Biol. 2015;12(2):162-74. doi: 10.1080/15476286.2015.1017220. RNA Biol. 2015. PMID: 25826568 Free PMC article.
-
A-to-I editing of protein coding and noncoding RNAs.Crit Rev Biochem Mol Biol. 2012 Nov-Dec;47(6):493-501. doi: 10.3109/10409238.2012.714350. Epub 2012 Sep 18. Crit Rev Biochem Mol Biol. 2012. PMID: 22988838 Review.
-
Global regulation of alternative splicing by adenosine deaminase acting on RNA (ADAR).RNA. 2013 May;19(5):591-604. doi: 10.1261/rna.038042.112. Epub 2013 Mar 8. RNA. 2013. PMID: 23474544 Free PMC article.
-
ADAR editing in double-stranded UTRs and other noncoding RNA sequences.Trends Biochem Sci. 2010 Jul;35(7):377-83. doi: 10.1016/j.tibs.2010.02.008. Epub 2010 Apr 8. Trends Biochem Sci. 2010. PMID: 20382028 Free PMC article. Review.
-
Developmental changes in expression and self-editing of adenosine deaminase type 2 pre-mRNA and mRNA in rat brain and cultured cortical neurons.Neurosci Res. 2008 Aug;61(4):398-403. doi: 10.1016/j.neures.2008.04.007. Epub 2008 Apr 26. Neurosci Res. 2008. PMID: 18534702
Cited by
-
What sequencing technologies can teach us about innate immunity.Immunol Rev. 2022 Jan;305(1):9-28. doi: 10.1111/imr.13033. Epub 2021 Nov 7. Immunol Rev. 2022. PMID: 34747035 Free PMC article. Review.
-
Noncoding regions of C. elegans mRNA undergo selective adenosine to inosine deamination and contain a small number of editing sites per transcript.RNA Biol. 2015;12(2):162-74. doi: 10.1080/15476286.2015.1017220. RNA Biol. 2015. PMID: 25826568 Free PMC article.
-
ADAR expression and copy number variation in patients with advanced gastric cancer.BMC Gastroenterol. 2020 May 14;20(1):152. doi: 10.1186/s12876-020-01299-8. BMC Gastroenterol. 2020. PMID: 32410589 Free PMC article.
-
Hepatitis B virus evades immune recognition via RNA adenosine deaminase ADAR1-mediated viral RNA editing in hepatocytes.Cell Mol Immunol. 2021 Aug;18(8):1871-1882. doi: 10.1038/s41423-021-00729-1. Epub 2021 Jul 12. Cell Mol Immunol. 2021. PMID: 34253859 Free PMC article.
-
Altered Regulation of adipomiR Editing with Aging.Int J Mol Sci. 2020 Sep 20;21(18):6899. doi: 10.3390/ijms21186899. Int J Mol Sci. 2020. PMID: 32962255 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials
