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Review
. 2013 Sep 1;22(129):265-72.
doi: 10.1183/09059180.00003613.

Common pathways in idiopathic pulmonary fibrosis and cancer

Carlo Vancheri  1
Affiliations
Review

Common pathways in idiopathic pulmonary fibrosis and cancer

Carlo Vancheri. Eur Respir Rev. .

Abstract

Idiopathic pulmonary fibrosis (IPF) is marked by a very disappointing survival rate and still represents a clinical dilemma. According to the current pathogenic hypothesis, chronic damage of the alveolar epithelium is followed by abnormal tissue repair and impairment of the alveolar structure. This process is driven by pathogenic events very similar to cancer, including epigenetic and genetic changes, altered response to regulatory signals, abnormal expression of microRNAs and activation of specific signalling pathways. IPF also resembles cancer with regard to its poor response to medical treatment and prognosis, which is very often worse than many cancers. We have hypothesised that IPF might be assimilated to a neoproliferative disorder of the lung. Viewing IPF as a cancer-like disease may satisfy the need for a better understanding of the pathogenesis of IPF by exploiting the large amount of knowledge that cancer biology evokes. The recognition of common pathogenic pathways between the two diseases may stimulate new clinical trials with cancer drugs, different drug combinations and different lines of drugs, as already experimented in oncology. Moreover, the concept of IPF as a cancer-like disorder may improve the attention given to this dreadful disease on a public, political and healthcare level.

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Conflict of interest statement

Conflict of interest: Disclosures can be found alongside the online version of this article at err.ersjournals.com

Figures

Figure 1.
Figure 1.
Scientific reasons for considering idiopathic pulmonary fibrosis (IPF) as a cancer-like disease.
Figure 2.
Figure 2.
Practical reasons for considering idiopathic pulmonary fibrosis (IPF) as a cancer-like disease.
See this image and copyright information in PMC

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