Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2013 Oct;14(10):673-85.
doi: 10.1038/nrm3644. Epub 2013 Aug 29.

Molecular control of the NEMO family of ubiquitin-binding proteins

Kristopher Clark  1 , Sambit Nanda, Philip Cohen
Affiliations
Review

Molecular control of the NEMO family of ubiquitin-binding proteins

Kristopher Clark et al. Nat Rev Mol Cell Biol. 2013 Oct.

Abstract

Research over the past decade has revealed how NF-κB essential modulator (NEMO; also known as IKKγ) regulates the IKKα-IKKβ signalling axis in the innate immune system. The discovery that NEMO is a polyubiquitin-binding protein and that the IKK complex is modulated by other protein kinases that are themselves controlled by polyubiquitin chains has provided a deeper molecular understanding of the non-degradative roles of ubiquitylation. New mechanistic insights of NEMO and related polyubiquitin-binding proteins have become a paradigm for how the interplay between phosphorylation and ubiquitylation controls cell signalling networks in health and disease.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Mol Cell. 2011 Nov 18;44(4):559-71 - PubMed
    1. J Biol Chem. 2002 Jul 5;277(27):24331-9 - PubMed
    1. Mol Cell. 2011 Feb 4;41(3):354-65 - PubMed
    1. Exp Eye Res. 2012 Mar;96(1):178-80 - PubMed
    1. Proc Natl Acad Sci U S A. 2008 Jan 29;105(4):1279-84 - PubMed

Publication types

LinkOut - more resources