PREEParing for mitosis
- PMID: 23948250
- DOI: 10.1016/j.devcel.2013.07.018
PREEParing for mitosis
Abstract
Reporting in Developmental Cell, Schlaitz et al. (2013) show that endoplasmic reticulum (ER) membrane exclusion from the mitotic spindle is an active process requiring REEP membrane proteins. REEP protein depletion results in ER membrane retention on the spindle and chromosomes, leading to defects in chromosome segregation and nuclear envelope assembly.
Copyright © 2013 Elsevier Inc. All rights reserved.
Comment on
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REEP3/4 ensure endoplasmic reticulum clearance from metaphase chromatin and proper nuclear envelope architecture.Dev Cell. 2013 Aug 12;26(3):315-23. doi: 10.1016/j.devcel.2013.06.016. Epub 2013 Aug 1. Dev Cell. 2013. PMID: 23911198 Free PMC article.
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