Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013 Sep-Oct;25(4):164-73.
doi: 10.1016/j.arteri.2013.07.001. Epub 2013 Aug 12.

[Alterations in the protein content and dysfunction of high-density lipoproteins from hyperhomocysteinemic mice]

[Article in Spanish]
Josep Julve  1 , Teresa Laura Errico, Xiangyu Chen, David Santos, Júlia Freixa, Inmaculada Porcel, Esther Cubero, Joan Carles Escolà-Gil, Francisco Blanco-Vaca
Affiliations

[Alterations in the protein content and dysfunction of high-density lipoproteins from hyperhomocysteinemic mice]

[Article in Spanish]
Josep Julve et al. Clin Investig Arterioscler. 2013 Sep-Oct.

Abstract

Aim: The aim of this study was to evaluate the proteic changes in high-density lipoproteins (HDL) induced by methionine-induced hyperhomocysteinemia in mice and its relationship with two of their main antiatherogenic properties.

Methods and results: The oral administration of methionine resulted in an elevation (~8 times) in the plasma concentration of homocysteine. Hyperhomocysteinemia was inversely correlated with the plasma concentration of HDL cholesterol and its main protein component of HDL, apolipoprotein (apo) A-I, respectively. The cholesterol efflux in vivo from macrophages to HDL was decreased in hyperhomocysteinemic mice compared with the control mice. However, the reverse cholesterol transport from macrophages to feces remained unchanged. On the other hand, the ability of HDL from hyperhomocysteinemic mice to prevent the oxidative modification of low-density lipoproteins (LDL) was found decreased and associated with a concomitant reduction in the plasma activity of paraoxonase-1 (PON1) and the plasma concentration of apoA-I, and with a relative reduction in the apoA-IV content (~1.5 times) in the hyperhomocysteinemic HDL, respectively.

Conclusion: The decrease in the ability of HDL from hyperhomocysteinemic mice to prevent LDL from oxidation was associated with a decrease in the apoA-I, PON1 and apoA-IV.

Keywords: High-density lipoproteins; Hiperhomocisteinemia; Hyperhomocysteinemia; Lipoproteínas de alta densidad; Proteomics; Proteómica.

PubMed Disclaimer

Similar articles

See all similar articles

Publication types

LinkOut - more resources