Dentin adhesion and MMPs: a comprehensive review
- PMID: 23910180
- DOI: 10.1111/jerd.12016
Dentin adhesion and MMPs: a comprehensive review
Abstract
This review examines the fundamental processes responsible for the aging mechanisms involved in the degradation of resin-bonded interfaces, as well as some potential approaches to prevent and counteract this degradation. Current research in several research centers aims at increasing the resin-dentin bond durability. The hydrophilic and acidic characteristics of current dentin adhesives have made hybrid layers highly prone to water sorption. This, in turn, causes polymer degradation and results in decreased resin-dentin bond strength over time. These unstable polymers inside the hybrid layer may result in denuded collagen fibers, which become vulnerable to mechanical and hydrolytical fatigue, as well as degradation by host-derived proteases with collagenolytic activity. These enzymes, such as matrix metalloproteinases and cysteine cathepsins, have a crucial role in the degradation of type I collagen, the organic component of the hybrid layer. This review will also describe several methods that have been recently advocated to silent the activity of these endogenous proteases.
© 2013 Wiley Periodicals, Inc.
Similar articles
-
Mechanisms of degradation of the hybrid layer in adhesive dentistry and therapeutic agents to improve bond durability--A literature review.Dent Mater. 2016 Feb;32(2):e41-53. doi: 10.1016/j.dental.2015.11.007. Epub 2015 Dec 29. Dent Mater. 2016. PMID: 26743967 Review.
-
The role of host-derived dentinal matrix metalloproteinases in reducing dentin bonding of resin adhesives.Int J Oral Sci. 2009 Dec;1(4):163-76. doi: 10.4248/IJOS.09044. Int J Oral Sci. 2009. PMID: 20690420 Free PMC article. Review.
-
Inhibition of enzymatic degradation of adhesive-dentin interfaces.J Dent Res. 2009 Dec;88(12):1101-6. doi: 10.1177/0022034509346952. Epub 2009 Oct 27. J Dent Res. 2009. PMID: 19861692
-
Role of dentin MMPs in caries progression and bond stability.J Dent Res. 2015 Feb;94(2):241-51. doi: 10.1177/0022034514562833. Epub 2014 Dec 22. J Dent Res. 2015. PMID: 25535202 Free PMC article. Review.
-
MMPs activity and bond strength in deciduous dentine-resin bonded interfaces.J Dent. 2013 Jun;41(6):549-55. doi: 10.1016/j.jdent.2013.02.008. Epub 2013 Feb 27. J Dent. 2013. PMID: 23454331
Cited by
-
The Classification and Selection of Adhesive Agents; an Overview for the General Dentist.Clin Cosmet Investig Dent. 2023 Sep 4;15:165-180. doi: 10.2147/CCIDE.S425024. eCollection 2023. Clin Cosmet Investig Dent. 2023. PMID: 37692095 Free PMC article. Review.
-
Two-year randomized clinical trial of different restorative techniques in non-carious cervical lesions and MMP activity in gingival crevicular fluid.Clin Oral Investig. 2022 Feb;26(2):1889-1902. doi: 10.1007/s00784-021-04166-2. Epub 2021 Sep 10. Clin Oral Investig. 2022. PMID: 34505916 Clinical Trial.
-
Erosive Influence of Amazonian Tucupi on Microshear Bond Strength to Enamel and Dentin.Contemp Clin Dent. 2024 Jul-Sep;15(3):186-191. doi: 10.4103/ccd.ccd_381_23. Epub 2024 Sep 25. Contemp Clin Dent. 2024. PMID: 39512291 Free PMC article.
-
Targeting Matrix Metalloproteinases in Cancer: Bringing New Life to Old Ideas.Genes Dis. 2015 Mar 1;2(`1):26-34. doi: 10.1016/j.gendis.2014.12.002. Genes Dis. 2015. PMID: 26097889 Free PMC article.
-
Effect of 2% Chlorhexidine Following Acid Etching on Microtensile Bond Strength of Resin Restorations: A Meta-Analysis.Medicina (Kaunas). 2019 Dec 2;55(12):769. doi: 10.3390/medicina55120769. Medicina (Kaunas). 2019. PMID: 31810222 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
