Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2013 Aug 1;188(3):279-84.
doi: 10.1164/rccm.201303-0503ED.

Two faces of vitamin E in the lung

Joan M Cook-Mills  1 , Hiam Abdala-Valencia, Tina Hartert
Affiliations
Review

Two faces of vitamin E in the lung

Joan M Cook-Mills et al. Am J Respir Crit Care Med. .

Abstract

Asthma and allergic lung disease occur as complex environmental and genetic interactions. Clinical studies of asthma indicate a number of protective dietary factors, such as vitamin E, on asthma risk. However, these studies have had seemingly conflicting outcomes. In this perspective, we discuss opposing regulatory effects of tocopherol isoforms of vitamin E, mechanisms for tocopherol isoform regulation of allergic lung inflammation, association of vitamin E isoforms with outcomes in clinical studies, and how the variation in global prevalence of asthma may be explained, at least in part, by vitamin E isoforms.

PubMed Disclaimer

Figures

<i>Figure 1.</i>
Figure 1.
α-Tocopherol and γ-tocopherol. (A) α-Tocopherol differs from γ-tocopherol by one methyl group (arrow). (B) Plasma γ-tocopherol (γ-T) and plasma α-tocopherol (α-T) in one to two reports per country and publication dates are indicated (, –83). Global asthma prevalence in 2004 (84) and 2012 (85). (C) Tocopherols were extracted from dietary oils (sunflower oil from Spectrum Organic Products, LLC; safflower oil from Spectrum; olive oil from Colavita; soybean oil from Crisco; corn oil from Mazola; grapeseed oil from Kusha, Inc; sesame oil from Lavita; peanut oil from Essentials by Supervalu; canola oil from Crisco; Sacha Inchi from Olivar). Extracted tocopherols were measured by HPLC with an electrochemical detector as previously described (8). ND = not determined.
See this image and copyright information in PMC

Comment in

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Martinez FD. Genes, environments, development and asthma: a reappraisal. Eur Respir J. 2007;29:179–184. - PubMed
    1. Bousquet J, Bousquet PJ, Godard P, Daures JP. The public health implications of asthma. Bull World Health Organ. 2005;83:548–554. - PMC - PubMed
    1. Vollmer WM, Osborne ML, Buist AS. 20-year trends in the prevalence of asthma and chronic airflow obstruction in an HMO. Am J Respir Crit Care Med. 1998;157:1079–1084. - PubMed
    1. Friebele E. The attack of asthma. Environ Health Perspect. 1996;104:22–25. - PMC - PubMed
    1. Uauy R, Hoffman DR, Birch EE, Birch DG, Jameson DM, Tyson J. Safety and efficacy of omega-3 fatty acids in the nutrition of very low birth weight infants: soy oil and marine oil supplementation of formula. J Pediatr. 1994;124:612–620. - PubMed

Publication types