Animal models of axon regeneration after spinal cord injury

doi:10.1007/s12264-013-1365-4

Review

. 2013 Aug;29(4):436-44.

doi: 10.1007/s12264-013-1365-4. Epub 2013 Jul 28.

Animal models of axon regeneration after spinal cord injury

Do-Hun Lee¹, Jae K Lee

Affiliations

PMID: 23893429
PMCID: PMC3920733
DOI: 10.1007/s12264-013-1365-4

Review

Animal models of axon regeneration after spinal cord injury

Do-Hun Lee et al. Neurosci Bull. 2013 Aug.

. 2013 Aug;29(4):436-44.

doi: 10.1007/s12264-013-1365-4. Epub 2013 Jul 28.

Authors

Do-Hun Lee¹, Jae K Lee

Affiliation

¹ Miami Project to Cure Paralysis, Department of Neurological Surgery, University of Miami School of Medicine, Miami, FL 33136, USA.

PMID: 23893429
PMCID: PMC3920733
DOI: 10.1007/s12264-013-1365-4

Abstract

With advances in genetic and imaging techniques, investigating axon regeneration after spinal cord injury in vivo is becoming more common in the literature. However, there are many issues to consider when using animal models of axon regeneration, including species, strains and injury models. No single particular model suits all types of experiments and each hypothesis being tested requires careful selection of the appropriate animal model. in this review, we describe several commonly-used animal models of axon regeneration in the spinal cord and discuss their advantages and disadvantages.

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References

1. Cafferty WB, McGee AW, Strittmatter SM. Axonal growth therapeutics: regeneration or sprouting or plasticity? Trends Neurosci. 2008;31:215–220. doi: 10.1016/j.tins.2008.02.004. - DOI - PMC - PubMed
1. Steward O, Zheng B, Tessier-Lavigne M. False resurrections: distinguishing regenerated from spared axons in the injured central nervous system. J Comp Neurol. 2003;459:1–8. doi: 10.1002/cne.10593. - DOI - PubMed
1. Tuszynski MH, Steward O. Concepts and methods for the study of axonal regeneration in the CNS. Neuron. 2012;74:777–791. doi: 10.1016/j.neuron.2012.05.006. - DOI - PMC - PubMed
1. Inman D, Guth L, Steward O. Genetic influences on secondary degeneration and wound healing following spinal cord injury in various strains of mice. J Comp Neurol. 2002;451:225–235. doi: 10.1002/cne.10340. - DOI - PubMed
1. Basso DM, Fisher LC, Anderson AJ, Jakeman LB, McTigue DM, Popovich PG. Basso Mouse Scale for locomotion detects differences in recovery after spinal cord injury in five common mouse strains. J Neurotrauma. 2006;23:635–659. doi: 10.1089/neu.2006.23.635. - DOI - PubMed

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[1] Cafferty WB, McGee AW, Strittmatter SM. Axonal growth therapeutics: regeneration or sprouting or plasticity? Trends Neurosci. 2008;31:215–220. doi: 10.1016/j.tins.2008.02.004. - DOI - PMC - PubMed

[2] Cafferty WB, McGee AW, Strittmatter SM. Axonal growth therapeutics: regeneration or sprouting or plasticity? Trends Neurosci. 2008;31:215–220. doi: 10.1016/j.tins.2008.02.004. - DOI - PMC - PubMed

[3] Steward O, Zheng B, Tessier-Lavigne M. False resurrections: distinguishing regenerated from spared axons in the injured central nervous system. J Comp Neurol. 2003;459:1–8. doi: 10.1002/cne.10593. - DOI - PubMed

[4] Steward O, Zheng B, Tessier-Lavigne M. False resurrections: distinguishing regenerated from spared axons in the injured central nervous system. J Comp Neurol. 2003;459:1–8. doi: 10.1002/cne.10593. - DOI - PubMed

[5] Tuszynski MH, Steward O. Concepts and methods for the study of axonal regeneration in the CNS. Neuron. 2012;74:777–791. doi: 10.1016/j.neuron.2012.05.006. - DOI - PMC - PubMed

[6] Tuszynski MH, Steward O. Concepts and methods for the study of axonal regeneration in the CNS. Neuron. 2012;74:777–791. doi: 10.1016/j.neuron.2012.05.006. - DOI - PMC - PubMed

[7] Inman D, Guth L, Steward O. Genetic influences on secondary degeneration and wound healing following spinal cord injury in various strains of mice. J Comp Neurol. 2002;451:225–235. doi: 10.1002/cne.10340. - DOI - PubMed

[8] Inman D, Guth L, Steward O. Genetic influences on secondary degeneration and wound healing following spinal cord injury in various strains of mice. J Comp Neurol. 2002;451:225–235. doi: 10.1002/cne.10340. - DOI - PubMed

[9] Basso DM, Fisher LC, Anderson AJ, Jakeman LB, McTigue DM, Popovich PG. Basso Mouse Scale for locomotion detects differences in recovery after spinal cord injury in five common mouse strains. J Neurotrauma. 2006;23:635–659. doi: 10.1089/neu.2006.23.635. - DOI - PubMed

[10] Basso DM, Fisher LC, Anderson AJ, Jakeman LB, McTigue DM, Popovich PG. Basso Mouse Scale for locomotion detects differences in recovery after spinal cord injury in five common mouse strains. J Neurotrauma. 2006;23:635–659. doi: 10.1089/neu.2006.23.635. - DOI - PubMed

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Animal models of axon regeneration after spinal cord injury

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Animal models of axon regeneration after spinal cord injury

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