CD4+CD25+Foxp3 regulatory T cells and vascular dysfunction in hypertension

doi:10.1097/HJH.0b013e328362feb7

Review

. 2013 Oct;31(10):1939-43.

doi: 10.1097/HJH.0b013e328362feb7.

CD4+CD25+Foxp3 regulatory T cells and vascular dysfunction in hypertension

Modar Kassan¹, Andrea Wecker, Philip Kadowitz, Mohamed Trebak, Khalid Matrougui

Affiliations

Affiliation

¹ aDepartment of Physiological Sciences, Eastern Virginia Medical School, Norfolk, Virginia bDepartment of Pharmacology, Tulane University, New Orleans, Louisiana cCollege of Nanoscale Science and Engineering, University at Albany, Albany, New York, USA.

PMID: 23881298
PMCID: PMC3915504
DOI: 10.1097/HJH.0b013e328362feb7

Review

CD4+CD25+Foxp3 regulatory T cells and vascular dysfunction in hypertension

Modar Kassan et al. J Hypertens. 2013 Oct.

. 2013 Oct;31(10):1939-43.

doi: 10.1097/HJH.0b013e328362feb7.

Authors

Modar Kassan¹, Andrea Wecker, Philip Kadowitz, Mohamed Trebak, Khalid Matrougui

Affiliation

¹ aDepartment of Physiological Sciences, Eastern Virginia Medical School, Norfolk, Virginia bDepartment of Pharmacology, Tulane University, New Orleans, Louisiana cCollege of Nanoscale Science and Engineering, University at Albany, Albany, New York, USA.

PMID: 23881298
PMCID: PMC3915504
DOI: 10.1097/HJH.0b013e328362feb7

Abstract

Endothelial dysfunction plays a key role in the development and progression of cardiovascular disease. In patients with hypertension, endothelial dysfunction is characterized by a decrease of vasodilator factors release. Recent evidence highlights the involvement of regulatory T cell in the cardiovascular physiology and pathology. An increasing body of data suggest that an imbalance in the immune system triggers inflammation and compromises the cardiovascular homeostasis. In this mini-review, we will highlight the role of immune regulatory T cells in hypertension-induced vascular dysfunction.

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Conflict of interest statement

Conflicts of interest

There are no conflicts of interest.

Comment in

Immune mechanisms in hypertension: how do T-regulatory lymphocytes fit in?
Schiffrin EL. Schiffrin EL. J Hypertens. 2013 Oct;31(10):1944-5. doi: 10.1097/HJH.0b013e3283638b52. J Hypertens. 2013. PMID: 24107725 No abstract available.
Regulatory T cells and vascular dysfunction.
Fernández-Fernández FJ. Fernández-Fernández FJ. J Hypertens. 2014 Jul;32(7):1542. doi: 10.1097/HJH.0000000000000191. J Hypertens. 2014. PMID: 24984179 No abstract available.

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References

1. Lewington S, Clarke R, Qizilbash N, Peto R, Collins R. Prospective Studies Collaboration. Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies. Lancet. 2002;360:1903–1913. - PubMed
1. Keenan NL, Rosendorf KA. Prevalence of hypertension and controlled hypertension-United States, 2005–2008. Centers for Disease Control and Prevention (CDC) MMWR Surveill Summ. 2011;60:94–97. - PubMed
1. Guzik TJ, Hoch NE, Brown KA, McCann LA, Rahman A, Dikalov S, et al. Role of the T cell in the genesis of angiotensin II induced hypertension and vascular dysfunction. J Exp Med. 2007;204:2449–2460. - PMC - PubMed
1. Ignarro LJ. Biological actions and properties of endothelium-derived nitric oxide formed and released from artery and vein. Circ Res. 1989;65:1–21. - PubMed
1. Feletou M, Vanhoutte PM. Endothelium-dependent hyperpolarization of canine coronary smooth muscle. Br J Pharmacol. 1988;93:515–524. - PMC - PubMed

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[1] Lewington S, Clarke R, Qizilbash N, Peto R, Collins R. Prospective Studies Collaboration. Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies. Lancet. 2002;360:1903–1913. - PubMed

[2] Lewington S, Clarke R, Qizilbash N, Peto R, Collins R. Prospective Studies Collaboration. Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies. Lancet. 2002;360:1903–1913. - PubMed

[3] Keenan NL, Rosendorf KA. Prevalence of hypertension and controlled hypertension-United States, 2005–2008. Centers for Disease Control and Prevention (CDC) MMWR Surveill Summ. 2011;60:94–97. - PubMed

[4] Keenan NL, Rosendorf KA. Prevalence of hypertension and controlled hypertension-United States, 2005–2008. Centers for Disease Control and Prevention (CDC) MMWR Surveill Summ. 2011;60:94–97. - PubMed

[5] Guzik TJ, Hoch NE, Brown KA, McCann LA, Rahman A, Dikalov S, et al. Role of the T cell in the genesis of angiotensin II induced hypertension and vascular dysfunction. J Exp Med. 2007;204:2449–2460. - PMC - PubMed

[6] Guzik TJ, Hoch NE, Brown KA, McCann LA, Rahman A, Dikalov S, et al. Role of the T cell in the genesis of angiotensin II induced hypertension and vascular dysfunction. J Exp Med. 2007;204:2449–2460. - PMC - PubMed

[7] Ignarro LJ. Biological actions and properties of endothelium-derived nitric oxide formed and released from artery and vein. Circ Res. 1989;65:1–21. - PubMed

[8] Ignarro LJ. Biological actions and properties of endothelium-derived nitric oxide formed and released from artery and vein. Circ Res. 1989;65:1–21. - PubMed

[9] Feletou M, Vanhoutte PM. Endothelium-dependent hyperpolarization of canine coronary smooth muscle. Br J Pharmacol. 1988;93:515–524. - PMC - PubMed

[10] Feletou M, Vanhoutte PM. Endothelium-dependent hyperpolarization of canine coronary smooth muscle. Br J Pharmacol. 1988;93:515–524. - PMC - PubMed

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CD4+CD25+Foxp3 regulatory T cells and vascular dysfunction in hypertension

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CD4+CD25+Foxp3 regulatory T cells and vascular dysfunction in hypertension

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Conflict of interest statement

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