CD4+CD25+Foxp3 regulatory T cells and vascular dysfunction in hypertension
- PMID: 23881298
- PMCID: PMC3915504
- DOI: 10.1097/HJH.0b013e328362feb7
CD4+CD25+Foxp3 regulatory T cells and vascular dysfunction in hypertension
Abstract
Endothelial dysfunction plays a key role in the development and progression of cardiovascular disease. In patients with hypertension, endothelial dysfunction is characterized by a decrease of vasodilator factors release. Recent evidence highlights the involvement of regulatory T cell in the cardiovascular physiology and pathology. An increasing body of data suggest that an imbalance in the immune system triggers inflammation and compromises the cardiovascular homeostasis. In this mini-review, we will highlight the role of immune regulatory T cells in hypertension-induced vascular dysfunction.
Conflict of interest statement
There are no conflicts of interest.
Comment in
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Immune mechanisms in hypertension: how do T-regulatory lymphocytes fit in?J Hypertens. 2013 Oct;31(10):1944-5. doi: 10.1097/HJH.0b013e3283638b52. J Hypertens. 2013. PMID: 24107725 No abstract available.
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Regulatory T cells and vascular dysfunction.J Hypertens. 2014 Jul;32(7):1542. doi: 10.1097/HJH.0000000000000191. J Hypertens. 2014. PMID: 24984179 No abstract available.
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