Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2013 Aug 1;12(15):2335-6.
doi: 10.4161/cc.25703. Epub 2013 Jul 15.

Ribosome-associated chaperones act as proteostasis sentinels

Janine Kirstein-Miles  1 , Richard I Morimoto
Affiliations
Editorial

Ribosome-associated chaperones act as proteostasis sentinels

Janine Kirstein-Miles et al. Cell Cycle. .
No abstract available

PubMed Disclaimer

Figures

None
Figure 1. Model of translational control in response to acute and chronic stress by the ribosome-associated chaperone NAC. Acute stress (upper branch) leads to a temporary translational decline due to sequestration of NAC by misfolded and aggregated proteins. Re-balancing of proteostasis by NAC and other molecular chaperones liberates NAC and allows for re-association with ribosomes and translation can resume. Chronic stress (lower branch) such as aging and polyQ expression leads to a terminal sequestration of NAC and, hence, a permanent decrease in protein synthesis.
See this image and copyright information in PMC

Comment on

Similar articles

See all similar articles

Cited by

References

    1. Kirstein-Miles J, Scior A, Deuerling E, Morimoto RI. The nascent polypeptide-associated complex is a key regulator of proteostasis. EMBO J. 2013;32:1451–68. doi: 10.1038/emboj.2013.87. - DOI - PMC - PubMed
    1. Walter P, Ron D. The unfolded protein response: from stress pathway to homeostatic regulation. Science. 2011;334:1081–6. doi: 10.1126/science.1209038. - DOI - PubMed
    1. Lindquist S. Translational efficiency of heat-induced messages in Drosophila melanogaster cells. J Mol Biol. 1980;137:151–8. doi: 10.1016/0022-2836(80)90322-8. - DOI - PubMed
    1. Liu B, Han Y, Qian SB. Cotranslational response to proteotoxic stress by elongation pausing of ribosomes. Mol Cell. 2013;49:453–63. doi: 10.1016/j.molcel.2012.12.001. - DOI - PMC - PubMed
    1. Shalgi R, Hurt JA, Krykbaeva I, Taipale M, Lindquist S, Burge CB. Widespread regulation of translation by elongation pausing in heat shock. Mol Cell. 2013;49:439–52. doi: 10.1016/j.molcel.2012.11.028. - DOI - PMC - PubMed

MeSH terms

Substances

LinkOut - more resources