Review
The ATM protein kinase: regulating the cellular response to genotoxic stress, and more
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Review
The ATM protein kinase: regulating the cellular response to genotoxic stress, and more
Nat Rev Mol Cell Biol.
2013 Apr.
Abstract
The protein kinase ataxia-telangiectasia mutated (ATM) is best known for its role as an apical activator of the DNA damage response in the face of DNA double-strand breaks (DSBs). Following induction of DSBs, ATM mobilizes one of the most extensive signalling networks that responds to specific stimuli and modifies directly or indirectly a broad range of targets. Although most ATM research has focused on this function, evidence suggests that ATM-mediated phosphorylation has a role in the response to other types of genotoxic stress. Moreover, it has become apparent that ATM is active in other cell signalling pathways involved in maintaining cellular homeostasis.
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