Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2013 Jul 2;105(1):3-10.
doi: 10.1016/j.bpj.2013.05.039.

Physical models of mesoderm invagination in Drosophila embryo

Matteo Rauzi  1 , Ana Hočevar Brezavšček, Primož Ziherl, Maria Leptin
Affiliations
Review

Physical models of mesoderm invagination in Drosophila embryo

Matteo Rauzi et al. Biophys J. .

Abstract

The invagination of the mesoderm in the Drosophila melanogaster embryo is an intensely studied example of epithelial folding. Several theoretical studies have explored the conditions and mechanisms needed to reproduce the formation of the invagination in silico. Here we discuss the aspects of epithelial folding captured by these studies, and compare the questions addressed, the approaches used, and the answers provided.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Overview of the main features of the models and their outcomes. The color-coded circular diagram in the center indicates whether a given feature is included in each of the eight models discussed. The level of complexity of the models is encoded by the number of black rectangles on the perimeter. Each model is illustrated by a representative predicted cross section of the embryo. The image on the left is a cross section of a gastrulating Drosophila embryo stained with antibodies against neurotactin, which labels the cell membrane (the inverted grayscale image of a fluorescent micrograph was kindly provided by Dr. G. Schäfer, University of Cologne).
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Conte V., Muñoz J.J., Miodownik M. A 3D finite element model of ventral furrow invagination in the Drosophila melanogaster embryo. J. Mech. Behav. Biomed. Mater. 2008;1:188–198. - PubMed
    1. Muñoz J.J., Barrett K., Miodownik M. A deformation gradient decomposition method for the analysis of the mechanics of morphogenesis. J. Biomech. 2007;40:1372–1380. - PubMed
    1. Pouille P.A., Farge E. Hydrodynamic simulation of multicellular embryo invagination. Phys. Biol. 2008;5:015005. - PubMed
    1. Odell G.M., Oster G., Burnside B. The mechanical basis of morphogenesis. I. Epithelial folding and invagination. Dev. Biol. 1981;85:446–462. - PubMed
    1. Allena R., Mouronval A.S., Aubry D. Simulation of multiple morphogenetic movements in the Drosophila embryo by a single 3D finite element model. J. Mech. Behav. Biomed. Mater. 2010;3:313–323. - PubMed

Publication types

LinkOut - more resources