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. 2013 Aug;28(4):209-15.
doi: 10.1007/s12250-013-3343-4. Epub 2013 Jun 26.

TRIM22 inhibits the TRAF6-stimulated NF-κB pathway by targeting TAB2 for degradation

Hui Qiu  1 , Fang Huang, Han Xiao, Binlian Sun, Rongge Yang
Affiliations

TRIM22 inhibits the TRAF6-stimulated NF-κB pathway by targeting TAB2 for degradation

Hui Qiu et al. Virol Sin. 2013 Aug.

Abstract

Tripartite motif containing 22 (TRIM22), a member of the TRIM/RBCC family, has been reported to activate the nuclear factor-kappa B (NF-κB) pathway in unstimulated macrophage cell lines, but the detailed mechanisms governing this activation remains unclear. We investigated this mechanism in HEK293T cells. We found that overexpression of TRIM22 could activate the NF-κB pathway and conversely, could inhibit the tumor necrosis factor receptor-associated factor 6 (TRAF6)-stimulated NF-κB pathway in HEK293T cells. Further experiments showed that TRIM22 could decrease the self-ubiquitination of TRAF6, and interact with and degrade transforming growth factor-β activated kinase 1 binding protein 2 (TAB2), and that these effects could be partially rescued by a TRIM22 RING domain deletion mutant. Collectively, our data indicate that overexpression of TRIM22 may negatively regulate the TRAF6-stimulated NF-κB pathway by interacting with and degrading TAB2.

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