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Review
. 2013 Sep;4(9):650-5.
doi: 10.1007/s13238-013-3040-y. Epub 2013 Jun 26.

Hedgehog in the Drosophila testis niche: what does it do there?

Zhao Zhang  1 , Chenyu Pan  2 , Yun Zhao  3
Affiliations
Review

Hedgehog in the Drosophila testis niche: what does it do there?

Zhao Zhang et al. Protein Cell. 2013 Sep.

Abstract

Stem cell niche is a specialized microenvironment crucial to self-renewal. The testis in Drosophila contains two different types of stem cells, the germline stem cells and the somatic cyst stem cells that are sustained by their respective niche signals, thus is a good system for studying the interaction between the stem cells and their hosting niche. The JAK-STAT and BMP pathways are known to play critical roles in the self-renewal of different kinds of stem cells, but the roles of several other pathways have emerged recently in a complex signaling network in the testis niche. Reports of independent observations from three research groups have uncovered an important role of Hedgehog (Hh) in the Drosophila testis niche. In this review, we summarize these recent findings and discuss the interplay between the Hh signaling mechanisms and those of the JAK-STAT and BMP pathways. We also discuss directions for further investigation.

Keywords: Drosophila; Hedgehog; JAK-STAT; stem cell; testis.

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References

    1. Affolter M, Basler K. The Decapentaplegic morphogen gradient: from pattern formation to growth regulation. Nat Rev Genet. 2007;8:663–674. doi: 10.1038/nrg2166. - DOI - PubMed
    1. Amoyel M, Sanny J, Burel M, Bach EA. Hedgehog is required for CySC self-renewal but does not contribute to the GSC niche in the Drosophila testis. Development. 2013;140:56–65. doi: 10.1242/dev.086413. - DOI - PMC - PubMed
    1. Apionishev S, Katanayeva NM, Marks SA, Kalderon D, Tomlinson A. Drosophila Smoothened phosphorylation sites essential for Hedgehog signal transduction. Nat Cell Biol. 2005;7:86–92. doi: 10.1038/ncb1210. - DOI - PubMed
    1. Aza-Blanc P, Ramirez-Weber FA, Laget MP, Schwartz C, Kornberg TB. Proteolysis that is inhibited by hedgehog targets Cubitus interruptus protein to the nucleus and converts it to a repressor. Cell. 1997;89:1043–1053. doi: 10.1016/S0092-8674(00)80292-5. - DOI - PubMed
    1. Bitgood MJ, Shen L, McMahon AP. Sertoli cell signaling by Desert hedgehog regulates the male germline. Curr Biol. 1996;6:298–304. doi: 10.1016/S0960-9822(02)00480-3. - DOI - PubMed

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