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. 2013 Jun 27:12:93.
doi: 10.1186/1476-511X-12-93.

Inflammation and impaired endothelium-dependant vasodilatation in non obese women with gestational diabetes mellitus: preliminary results

Ines Mrizak  1 , Amel Arfa, Mariem Fekih, Haythem Debbabi, Ali Bouslema, Imen Boumaiza, Monia Zaouali, Naim A Khan, Zouhair Tabka
Affiliations

Inflammation and impaired endothelium-dependant vasodilatation in non obese women with gestational diabetes mellitus: preliminary results

Ines Mrizak et al. Lipids Health Dis. .

Abstract

Background: To evaluate whether abnormal endothelial function, a common finding in gestational diabetes mellitus (GDM) pregnancies, can be explained by inflammatory cytokines.

Methods: Forearm skin blood flow (FSBF), into response to acetylcholine (Ach) (endothelium-dependent vasodilatation), were measured in 24 pregnant control subjects and 28 gestational diabetes mellitus (GDM) women, in the third trimester of gestation. A fasting glycemic and lipidic panel was obtained, and inflammatory cytokines (TNF-α and IL-6) and adiponectin were also determined.

Results: FSBF is significantly reduced in GDM group compared with control subjects (344.59 ± 57.791 vs.176.38 ± 108.52, P < 0.05). Among all subjects, FSBF showed a strong negative correlation with TNF-α and IL-6 (r = -0.426, P < 0.0001 and r = -0.564, P < 0.0001, respectively) and positive correlation with adiponectin (r = 0.468, P < 0.0001).

Conclusions: Endothelial function, an early marker of macrovascular disease, is present in non-obese pregnancies complicated by GDM. This alteration seems to be directly related to inflammatory status, which may represent a patho-physiological link between GDM and type 2 diabetes and, later on, metabolic syndrome.

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Figures

Figure 1
Figure 1
Linear regression analysis of percentage increase in FSBF and adiponectin.
Figure 2
Figure 2
Linear regression analysis of percentage increase in FSBF and IL-6.
Figure 3
Figure 3
Linear regression analysis of percentage increase in FSBF and TNF-α.
See this image and copyright information in PMC

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References

    1. American Diabetes Association. Diagnosis and Classification of Diabetes Mellitus. Diabetes Care. 2006;29(1):43–48. - PubMed
    1. Hanna FW, Peters JR, Harlow J, Jones PW. Gestational diabetes screening and glycaemic management; national survey on behalf of the Association of British Clinical Diabetologists. QJM. 2008;101(10):777–784. doi: 10.1093/qjmed/hcn069. - DOI - PubMed
    1. Wolf M, Sauk J, Shah A, Vossen Smirnakis K, Jimenez-Kimble R, Ecker JL, Thadhani R. Inflammation and glucose intolerance: a prospective study of gestational diabetes mellitus. Diabetes Care. 2004;27(1):21–27. doi: 10.2337/diacare.27.1.21. - DOI - PubMed
    1. Richardson AC, Carpenter MW. Inflammatory mediators in gestational diabetes mellitus. Obstet Gynecol Clin North Am. 2007;34(2):213–224. doi: 10.1016/j.ogc.2007.04.001. - DOI - PubMed
    1. Black PH. The inflammatory consequences of psychologic stress: relationship to insulin resistance, obesity, atherosclerosis and diabetes mellitus, type II. Med Hypotheses. 2006;67(4):879–891. doi: 10.1016/j.mehy.2006.04.008. - DOI - PubMed

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