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. 2012 Oct;39(5):348-52.
doi: 10.1159/000342231. Epub 2012 Sep 6.

CD47 in Erythrocyte Ageing and Clearance - the Dutch Point of View

Patrick Burger  1 , Dirk de Korte, Timo K van den Berg, Robin van Bruggen
Affiliations

CD47 in Erythrocyte Ageing and Clearance - the Dutch Point of View

Patrick Burger et al. Transfus Med Hemother. 2012 Oct.

Abstract
in English, German

Recently, an important role for CD47, a well-known 'don't eat me' signal, in the clearance of aged erythrocytes was revealed. Experimental data support the conversion of CD47 from a 'don't eat me' to an 'eat me' signal through a conformational change in CD47. Intriguingly, erythrocyte phagocytosis after this switch seems to be mediated by the same receptor that normally signals inhibition of phagocytosis, SIRPα. In this review, the possible molecular mechanisms leading to this conformational change in CD47 as well as the possible signal transduction events leading to phagocytosis after this switch are discussed. Lastly, the consequences of this newly identified mode of erythrocyte phagocytosis for the clearance of aged erythrocytes during normal turnover and after erythrocyte transfusion are addressed.

Vor kurzem ist eine wichtige Rolle für CD47, einem bekannten ‘Don't-Eat-Me’-Signal, bei der Beseitigung gealterter Erythrozyten aufgedeckt worden. Experimentelle Daten belegen die Umwandlung von CD47 von einem ‘Don't-Eat-Me’- zu einem ‘Eat-Me’-Signal durch konformative Veränderungen. Interessanterweise scheint die Erythrozytenphagozytose nach der Umwandlung von dem gleichen Rezeptor (SIRPα) vermittelt zu werden, der normalerweise die Hemmung der Phagozytose signalisiert. In dieser Übersichtsarbeit werden sowohl die potentiellen molekularen Mechanismen, die zu dieser Umwandlung von CD47 führen, als auch die möglichen Signaltransduktionsvorgänge, die nach der Umwandlung die Phagozytose einleiten, diskutiert. Des Weiteren werden die Konsequenzen dieses neu identifizierten Modus der Erythrozytenphagozytose für die Beseitigung gealterter Erythrozyten während des normalen Turnovers sowie nach Erythrozytentransfusion beleuchtet.

Keywords: Aged erythrocytes; CD47; Phagocytosis; SIRPα.

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Figures

Fig. 1
Fig. 1
Oxidation and ageing cause a conformational change in CD47 upon which TSP-1 can bind. Under normal conditions, CD47 on the erythrocyte inhibits phagocytosis by interaction with SIRPα on the phagocyte. After the conformational change in CD47, TSP-1 is able to bind upon which interaction between CD47 and SIRPα leads to phagocytosis.
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