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Review
. 2013 Oct;25(10):1970-80.
doi: 10.1016/j.cellsig.2013.06.003. Epub 2013 Jun 11.

Inhibitor of apoptosis proteins (IAPs) as regulatory factors of hepatic apoptosis

Kewei Wang  1 , Bingliang Lin
Affiliations
Review

Inhibitor of apoptosis proteins (IAPs) as regulatory factors of hepatic apoptosis

Kewei Wang et al. Cell Signal. 2013 Oct.

Abstract

IAPs are a group of regulatory proteins that are structurally related. Their conserved homologues have been identified in various organisms. In human, eight IAP members have been recognized based on baculoviral IAP repeat (BIR) domains. IAPs are key regulators of apoptosis, cytokinesis and signal transduction. The antiapoptotic property of IAPs depends on their professional role for caspases. IAPs are functionally non-equivalent and regulate effector caspases through distinct mechanisms. IAPs impede apoptotic process via membrane receptor-dependent (extrinsic) cascade and mitochondrial dependent (intrinsic) pathway. IAP-mediated apoptosis affects the progression of liver diseases. Therapeutic options of liver diseases may depend on the understanding toward mechanisms of the IAP-mediated apoptosis.

Keywords: APAF-1; ASO; Antisense oligonucleotides; BIR; Baculovirus IAP repeat; CD2; CDK4; Caspase; FLICE-inhibitory proteins; FLIPs; HCC; HSP90; Hepatic apoptosis; IAPs; NF-κB; RIP1; Rb; Second mitochondria-derived activator of caspase/direct inhibitor of apoptosis-binding protein with low pI; Smac/Diablo; TNF; TNF receptor-associated factor 2; TRAF2; apoptotic protease activating factor 1; cluster of differentiation 2; cyclin dependent kinase 4; heat shock protein 90; hepatocellular carcinoma; inhibitor of apoptosis proteins; nuclear factor kappa-light-chain-enhancer of activated B cells; receptor-interacting protein 1; retinoblastoma; tumor necrosis factor.

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