Abstract

Keywords: 1-d-myo-inositol-phosphate synthase; 5′ AMP-activated protein kinase; AC; ACC; AGEs; AMP; AMPK; AUC; BMI; Body Mass Index; CDP-DAG; D-chiro-inositol; DCI; Diabetes; Diabetic neuropathy; ECM; FA; FSH; G3PAT; GFR; GK; GLUT-4; GMD; GPI; GS; GSK3; Goto Kakizaki (rat); H(+)/myo-inositol transporter; HDL; HK; HMIT; HOMA-IR; IMPase; INS-2; IPG; IPs; IR; IRS; Inositol; Insulin resistance; LD50; LDL; LH; LysoPI; MI; MIOX; MIPS; MNCV; MetS; Metabolic syndrome; OGTT; PCOS; PDH; PDHP; PDK; PI; PI3K; PIPs; PKA; PKB; PKC; PLC; PLD; PP-InsPs; PP2Cα; Polycystic ovary syndrome; Protein Kinase B; RCT; SHBG; SHR; SMIT1/2; STZ; Sex Hormon Binding Globulin; acetyl-coenzyme A carboxylase; adenosine monophosphate; adenylyl cyclase; advanced glycation end products; area under the curve; cAMP; cyclic AMP; cyclic AMP-dependent protein kinase; cytidine diphosphate-diacylglycerol; extracellular matrix; folic acid; follicle-stimulating hormone; gestational diabetes mellitus; glomerular filtration rate; glucose transporter 4; glycerol-3-phosphate acyltransferase; glycogen synthase; glycogen synthase kinase 3; glycosyl phosphatidylinositol; hexokinase; high density lipoprotein; homeostasis model assessment of insulin resistance; inositol monophosphatase; inositol phosphates (including in particular: Ins-P: inositol monophosphate, IP3, inositol triphosphates, IP6, inositol hexakisphosphates or phytic acid); inositol phosphoglycan; insulin receptor; insulin receptor substrate(s); insulin second messenger with a 4-O-(2-amino-2-deoxy-beta-d-galactopyranosyl)-3-O-methyl-d-chiro-inositol structure; low density lipoprotein; luteinizing hormone; lysophosphatidylinositol; mTOR; mammalian target of rapamycin; median lethal dose; metabolic syndrome; motor nerve conduction velocity; myo-inositol; myo-inositol oxygenase; oral glucose tolerance test; phosphatidylinositol; phosphatidylinositol phosphate lipids (including PIP(2), phosphatidylinositol 4,5-bisphosphate and PIP(3), phosphatidylinositol (3,4,5)-trisphosphate); phosphatidylinositol-3-kinase(s); phosphoinositide-dependent kinase; phospholipase C; phospholipase D; phosphoprotein phosphatase 2C alpha; polycystic ovary syndrome; protein kinase C; pyrophosphate forms of inositol phosphates; pyruvate dehydrogenase; pyruvate dehydrogenase phosphatase; randomized controlled trial; sodium-dependant myo-inositol transporter 1/2; spontaneously hypertensive rat; streptozotocin.