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Review
. 2013 May 21;19(19):2847-63.
doi: 10.3748/wjg.v19.i19.2847.

Chemokines, chemokine receptors and the gastrointestinal system

Hiroshi Miyazaki  1 , Kazuaki Takabe, W Andrew Yeudall
Affiliations
Review

Chemokines, chemokine receptors and the gastrointestinal system

Hiroshi Miyazaki et al. World J Gastroenterol. .

Abstract

The biological properties of tumor cells are known to be regulated by a multitude of cytokines and growth factors, which include epidermal growth factor receptor agonists and members of the transforming growth factor β family. Furthermore, the recent explosion of research in the field of chemokine function as mediators of tumor progression has led to the possibility that these small, immunomodulatory proteins also play key roles in carcinogenesis and may, therefore, be potential targets for novel therapeutic approaches. In this review, we will summarize recently reported findings in chemokine biology with a focus on the gastrointestinal tract.

Keywords: Cancer; Chemokine; Digestive system; Receptor; Signal transduction; Targeted therapeutics; Tumor progression.

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Figures

Figure 1
Figure 1
Chemokine-induced signal transduction pathways. Schematic representation of signaling pathways activated by binding of chemokine ligands to their seven transmembrane G-protein coupled receptors. MMPs: Matrix metalloproteinases; TFs: Transcription factors; RTK: Receptor tyrosine kinase; ERK: Extracellular signal-regulated kinase; MEK: Mitogen-activated protein/extracellular signal-regulated kinase kinase; PI-3K: Phosphatidyl inositide-3-OH kinase; MKK: Mitogen-activated protein kinase kinase; JNK: c-Jun N-terminal kinase; AKT: Protein kinase B.
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