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. 2013:2013:761314.
doi: 10.1155/2013/761314. Epub 2013 Mar 14.

Cardiovascular changes in animal models of metabolic syndrome

Alexandre M Lehnen  1 , Bruno Rodrigues, Maria Cláudia Irigoyen, Kátia De Angelis, Beatriz D'Agord Schaan
Affiliations

Cardiovascular changes in animal models of metabolic syndrome

Alexandre M Lehnen et al. J Diabetes Res. 2013.

Abstract

Metabolic syndrome has been defined as a group of risk factors that directly contribute to the development of cardiovascular disease and/or type 2 diabetes. Insulin resistance seems to have a fundamental role in the genesis of this syndrome. Over the past years to the present day, basic and translational research has used small animal models to explore the pathophysiology of metabolic syndrome and to develop novel therapies that might slow the progression of this prevalent condition. In this paper we discuss the animal models used for the study of metabolic syndrome, with particular focus on cardiovascular changes, since they are the main cause of death associated with the condition in humans.

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Figures

Figure 1
Figure 1
Components of the metabolic syndrome and its relation to the principal cardiovascular phenotypes. IR/GI: insulin resistance/glucose intolerance; HRV: heart rate variability; LV: left ventricular.
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References

    1. Alberti KGMM, Zimmet P, Shaw J. Metabolic syndrome—a new world-wide definition. A consensus statement from the International Diabetes Federation. Diabetic Medicine. 2006;23(5):469–480. - PubMed
    1. Defina LF, Vega GL, Leonard D, Grundy SM. Fasting glucose, obesity, and metabolic syndrome as predictors of type 2 diabetes: the cooper center longitudinal study. Journal of Investigative Medicine. 2012;60(8):1164–1168. - PubMed
    1. Dekker JM, Girman C, Rhodes T, et al. Metabolic syndrome and 10-year cardiovascular disease risk in the Hoorn Study. Circulation. 2005;112(5):666–673. - PubMed
    1. Mulè G, Nardi E, Cottone S, et al. Influence of metabolic syndrome on hypertension-related target organ damage. Journal of Internal Medicine. 2005;257(6):503–513. - PubMed
    1. de las Fuentes L, Brown AL, Mathews SJ, et al. Metabolic syndrome is associated with abnormal left ventricular diastolic function independent of left ventricular mass. European Heart Journal. 2007;28(5):553–559. - PubMed

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