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Review
. 2013 Sep;27(9):3424-9.
doi: 10.1096/fj.12-223842. Epub 2013 May 16.

Dysfunction of the autophagy/lysosomal degradation pathway is a shared feature of the genetic synucleinopathies

Claudia Manzoni  1 , Patrick A Lewis
Affiliations
Review

Dysfunction of the autophagy/lysosomal degradation pathway is a shared feature of the genetic synucleinopathies

Claudia Manzoni et al. FASEB J. 2013 Sep.

Abstract

The past decade has witnessed huge advances in our understanding of the genetics underlying Parkinson's disease. Identifying commonalities in the biological function of genes linked to Parkinson's provides an opportunity to elucidate pathways that lead to neuronal degeneration and eventually to disease. We propose that the genetic forms of Parkinson's disease largely associated with α-synuclein-positive neuropathology (SNCA, LRRK2, and GBA) are brought together by involvement in the autophagy/lysosomal pathway and that this represents a unifying pathway to disease in these cases.

Keywords: GBA; LRRK2; Parkinson's disease.

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Figures

Figure 1
Figure 1. Links between the genetic synucleinopathies.
Venn diagram illustrating the overlaps between the key genes discussed in this review and their physiological roles. Solid arrows indicate reported biological interactions, dotted arrow represents untested interaction.
Figure 2
Figure 2. Autophagy/lysosomal pathways to PD: hypothetical framework for the interaction of the genes implicated in the genetic synucleopathies at the convergence of the autophagy and lysosomal pathways showing location of the genes discussed in the text.
See this image and copyright information in PMC

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