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. 2008 Mar;4(1):58-63.

Clinicopathological Significance of VEGF-C, VEGFR-3 and Cyclooxygenase-2 in Early-Stage Cervical Cancer

Xiaoyan Shi  1 , Ling Xi, Danhui Weng, Gang Chen, Xiaohong Song, Peng Wu, Beibei Wang, Juncheng Wei, Shixuan Wang, Jianfeng Zhou, Ding Ma
Affiliations

Clinicopathological Significance of VEGF-C, VEGFR-3 and Cyclooxygenase-2 in Early-Stage Cervical Cancer

Xiaoyan Shi et al. Int J Biomed Sci. 2008 Mar.

Abstract

To investigate the roles of VEGF-C, VEGFR-3 and cyclooxygenase-2 (COX-2) in tumor progression and lymph node metastasis. The expression of VEGF-C, VEGFR-3 and COX-2 were examined in 93 cases of surgical speciments of cervical diseases by immunohistochemical staining. The correlation between expression of these factors and tumor aggressiveness was evaluated. The expression levels of VEGF-C and COX-2 were much higher in cervical cancer than in cervical intraepithelial neoplasia (CIN) and in chronic cervicitis. VEGF-C expression correlated with lymph node metastases (P<0.01). Multivariate analysis indicated that lymph vessel density (LVD) was associated with the coexpression of VEGF-C and COX-2. Expression of VEGF-C and VEGFR-3 were both in coincidence with lymph node metastasis. VEGF-C and COX-2 may promote the canceration of cervical cancer and that VEGF-C/ VEGFR-3 system had a significant association with the lymphagiogenesis and lymph node metastasis.

Keywords: cervical cancer; cyclooxygenase-2; lymph node metastasis; lymphagiogenesis; vascular endothelial growth factor receptor-3; vascular endothelial growth factor-C.

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Figures

Figure 1
Figure 1
Immunohistochemical staining of VEGF-C, VEGFR-3 and COX-2. A, VEGF-C was stained in the cytoplasm of cervical cancer cells. B, VEGFR-3 expressed in the lymphatic vessels of the stromal adjacent to tumor nest. C, COX-2 was stained in the cytoplasm of cervical cancer cells.
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References

    1. Recio FO, Sahai Srivastava BI, Wong C, Hempling RE, et al. The clinical value of digene hybrid capture HPV DNA testing in a referral-based population with abnormal pap smears. Eur. J. Gynaecol. Oncol. 1998;19:203–208. - PubMed
    1. Birner P, Obermair A, Schindl M, Kowalski H, et al. Selective immunohistochemical staining of blood and lymphatic vessels reveals independent prognostic influence of blood and lymphatic vessel invasion in early-stage cervical cancer. Clin. Cancer Res. 2001;7:93–97. - PubMed
    1. Birner P, Schindl M, Obermair A, Breitenecker G. Lymphatic microvessel density as a novel prognostic factor in early-stage invasive cervical cancer. Int. J. Cancer. 2001;95:29–33. - PubMed
    1. Joukov V, Pajusola K, Kaipainen A, et al. A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases. EMBO J. 1996;15:290–298. - PMC - PubMed
    1. Skobe M, Hawighorst T, Jackson DG, et al. Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasis. Nat. Med. 2001;7:192–198. - PubMed

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