Review
doi: 10.1016/j.molmed.2013.04.003.
Epub 2013 May 8.
Painful Na-channelopathies: an expanding universe
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- PMID: 23664154
- DOI: 10.1016/j.molmed.2013.04.003
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Review
Painful Na-channelopathies: an expanding universe
Trends Mol Med.
2013 Jul.
Abstract
The universe of painful Na-channelopathies--human disorders caused by mutations in voltage-gated sodium channels--has recently expanded in three dimensions. We now know that mutations of sodium channels cause not only rare genetic 'model disorders' such as inherited erythromelalgia and channelopathy-associated insensitivity to pain but also common painful neuropathies. We have learned that mutations of NaV1.8, as well as mutations of NaV1.7, can cause painful Na-channelopathies. Moreover, recent studies combining atomic level structural models and pharmacogenomics suggest that the goal of genomically guided pain therapy may not be unrealistic.
Copyright © 2013 Elsevier Ltd. All rights reserved.
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