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Review
. 2013:117:187-205.
doi: 10.1016/B978-0-12-386931-9.00008-8.

G protein-coupled receptor heterocomplexes in neuropsychiatric disorders

José L Moreno  1 , Terrell Holloway, Javier González-Maeso
Affiliations
Review

G protein-coupled receptor heterocomplexes in neuropsychiatric disorders

José L Moreno et al. Prog Mol Biol Transl Sci. 2013.

Abstract

G protein-coupled receptors (or GPCRs) represent the largest family of membrane proteins in the human genome and are the target of approximately half of all therapeutic drugs. GPCRs contain a conserved structure of seven transmembrane domains. Their amino terminus is located extracellularly, whereas the carboxy terminus extends into the cytoplasm. Accumulating evidence suggests that GPCRs exist and function as monomeric entities. Nevertheless, more recent findings indicate that GPCRs can also form dimers or even higher order oligomers. The differential pharmacological and signaling properties of GPCR heteromeric complexes hint that their physiological effects may be different as compared to those obtained in tissue cultures that express a particular GPCR. In this chapter, we review current data on the role of GPCR heteromerization in receptor signaling, as well as its potential implication in neuropsychiatric disorders such as schizophrenia, depression, and Parkinson's disease.

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Figures

Figure 8.1
Figure 8.1
Schematic model of functional responses induced by GPCR homomers as compared to GPCR heteromers. Combinations of drugs modulate different patterns of signaling responses, and a cross talk between the components of the GPCR heteromeric complex leads to unique signaling properties.
See this image and copyright information in PMC

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