ERAP1 in ankylosing spondylitis: genetics, biology and pathogenetic role
- PMID: 23656713
- DOI: 10.1097/BOR.0b013e328362042f
ERAP1 in ankylosing spondylitis: genetics, biology and pathogenetic role
Abstract
Purpose of review: Endoplasmic reticulum aminopeptidase 1 (ERAP1) is an aminopeptidase of the endoplasmic reticulum involved in trimming of peptides to their optimal size for binding to major histocompatibility complex class I molecules. Natural ERAP1 polymorphism resulting in altered enzymatic activity is associated with ankylosing spondylitis, an inflammatory disorder very strongly linked to HLA-B27.
Recent findings: This review will summarize recent advances in the genetics of ERAP1 association with this disease, in the molecular basis of ERAP1 function and in the mechanism of functional interaction between ERAP1 and HLA-B27.
Summary: The findings suggest that the pathogenetic role of ERAP1 in ankylosing spondylitis is due to allotype-dependent alterations of the HLA-B27 peptidome that affect the immunologic and other features of HLA-B27.
Similar articles
-
ERAP1 structure, function and pathogenetic role in ankylosing spondylitis and other MHC-associated diseases.Mol Immunol. 2014 Jan;57(1):12-21. doi: 10.1016/j.molimm.2013.06.012. Epub 2013 Jul 31. Mol Immunol. 2014. PMID: 23916068 Review.
-
KIR3DL1 interaction with HLA-B27 is altered by ankylosing spondylitis associated ERAP1 and enhanced by MHC class I cross-linking.Discov Med. 2015 Jul-Aug;20(108):79-89. Discov Med. 2015. PMID: 26321090
-
Combined effects of ankylosing spondylitis-associated ERAP1 polymorphisms outside the catalytic and peptide-binding sites on the processing of natural HLA-B27 ligands.J Biol Chem. 2014 Feb 14;289(7):3978-90. doi: 10.1074/jbc.M113.529610. Epub 2013 Dec 18. J Biol Chem. 2014. PMID: 24352655 Free PMC article.
-
ERAP1 and ankylosing spondylitis.Curr Opin Immunol. 2013 Feb;25(1):97-102. doi: 10.1016/j.coi.2012.11.002. Curr Opin Immunol. 2013. PMID: 23452840 Review.
-
Separate effects of the ankylosing spondylitis associated ERAP1 and ERAP2 aminopeptidases determine the influence of their combined phenotype on the HLA-B*27 peptidome.J Autoimmun. 2017 May;79:28-38. doi: 10.1016/j.jaut.2016.12.008. Epub 2017 Jan 4. J Autoimmun. 2017. PMID: 28063628
Cited by
-
Polymorphism of HLA-B27: 105 subtypes currently known.Curr Rheumatol Rep. 2013 Oct;15(10):362. doi: 10.1007/s11926-013-0362-y. Curr Rheumatol Rep. 2013. PMID: 23990399 Review.
-
HLA-B27 may modulate the interaction between ERAP1 polymorphisms and smoking in ankylosing spondylitis patients.Mol Biol Rep. 2022 Jul;49(7):6423-6431. doi: 10.1007/s11033-022-07456-4. Epub 2022 Apr 16. Mol Biol Rep. 2022. PMID: 35430705 Free PMC article.
-
A proposed HLA-B*27 screening method for ankylosing spondylitis detection based on tag-single nucleotide polymorphisms: a preliminary study.Mol Biol Rep. 2021 Dec;48(12):7819-7829. doi: 10.1007/s11033-021-06801-3. Epub 2021 Oct 13. Mol Biol Rep. 2021. PMID: 34643924
-
Functional ERAP1 Variants Distinctively Associate with Ankylosing Spondylitis Susceptibility under the Influence of HLA-B27 in Taiwanese.Cells. 2022 Aug 5;11(15):2427. doi: 10.3390/cells11152427. Cells. 2022. PMID: 35954271 Free PMC article.
-
Structure-guided discovery of aminopeptidase ERAP1 variants capable of processing antigens with novel PC anchor specificities.Immunology. 2024 Jan;171(1):131-145. doi: 10.1111/imm.13709. Epub 2023 Oct 19. Immunology. 2024. PMID: 37858978 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials
Miscellaneous
