Therapeutic strategies for tendon healing based on novel biomaterials, factors and cells
- PMID: 23652284
- DOI: 10.1159/000347059
Therapeutic strategies for tendon healing based on novel biomaterials, factors and cells
Abstract
The repair of tendon injuries still presents a major clinical challenge to orthopedic medicine. Tendons, like some other tissues, are poorly vascularized and heal slowly. In addition, healing often leads to the formation of fibrous tissue and scar tissue which lack flexibility and biomechanical properties. So the treatment of tendon injuries is challenging. We give an overview of the structure and composition of tendons, pathological states of tendon and natural healing, as well as therapeutic options. We focus in particular on biomaterials that have been specifically developed or suggested for the successful repair of tendon injuries. In addition, we also review factor- and cell-dependent strategies to heal tendon and ligament disorders. Although brief, we hope that this review will be helpful, particularly for those readers who are new to the field of tendon tissue engineering.
Copyright © 2013 S. Karger AG, Basel.
Similar articles
-
Tendon and ligament engineering: from cell biology to in vivo application.Regen Med. 2006 Jul;1(4):563-74. doi: 10.2217/17460751.1.4.563. Regen Med. 2006. PMID: 17465850 Review.
-
Stem cells for tendon and ligament tissue engineering and regeneration.J Stem Cells. 2010;5(4):187-94. J Stem Cells. 2010. PMID: 22314867 Review.
-
Regeneration and repair of tendon and ligament tissue using collagen fibre biomaterials.Acta Biomater. 2011 Sep;7(9):3237-47. doi: 10.1016/j.actbio.2011.06.002. Epub 2011 Jun 13. Acta Biomater. 2011. PMID: 21689792 Review.
-
Response of donor and recipient cells after transplantation of cells to the ligament and tendon.Microsc Res Tech. 2002 Jul 1;58(1):34-8. doi: 10.1002/jemt.10114. Microsc Res Tech. 2002. PMID: 12112420 Review.
-
[Analysis of Musculoskeletal Systems and Their Diseases. Pathology and treatment for injuries of the tendon and ligament].Clin Calcium. 2015 Aug;25(8):1205-11. Clin Calcium. 2015. PMID: 26224679 Japanese.
Cited by
-
Natural, synthetic and commercially-available biopolymers used to regenerate tendons and ligaments.Bioact Mater. 2022 Apr 13;19:179-197. doi: 10.1016/j.bioactmat.2022.04.003. eCollection 2023 Jan. Bioact Mater. 2022. PMID: 35510172 Free PMC article. Review.
-
Gene expression profiling of progenitor cells isolated from rat rotator cuff musculotendinous junction.BMC Musculoskelet Disord. 2020 Mar 28;21(1):194. doi: 10.1186/s12891-020-03190-9. BMC Musculoskelet Disord. 2020. PMID: 32222148 Free PMC article.
-
Transcriptome analysis of ageing in uninjured human Achilles tendon.Arthritis Res Ther. 2015 Feb 18;17(1):33. doi: 10.1186/s13075-015-0544-2. Arthritis Res Ther. 2015. PMID: 25888722 Free PMC article.
-
Apoptotic Body-Rich Media from Tenocytes Enhance Proliferation and Migration of Tenocytes and Bone Marrow Stromal Cells.Int J Mol Sci. 2022 Sep 29;23(19):11475. doi: 10.3390/ijms231911475. Int J Mol Sci. 2022. PMID: 36232777 Free PMC article.
-
Platelet concentration in platelet-rich plasma affects tenocyte behavior in vitro.Biomed Res Int. 2014;2014:630870. doi: 10.1155/2014/630870. Epub 2014 Jul 23. Biomed Res Int. 2014. PMID: 25147809 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
