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. 2012 Nov 1;7(11):1077-1088.
doi: 10.2217/fvl.12.108.

Role of T-cell epitope-based vaccine in prophylactic and therapeutic applications

James S Testa  1 , Ramila Philip
Affiliations

Role of T-cell epitope-based vaccine in prophylactic and therapeutic applications

James S Testa et al. Future Virol. .

Abstract

Prophylactic and therapeutic vaccines against viral infections have advanced in recent years from attenuated live vaccines to subunit-based vaccines. An ideal prophylactic vaccine should mimic the natural immunity induced by an infection, in that it should generate long-lasting adaptive immunity. To complement subunit vaccines, which primarily target an antibody response, different methodologies are being investigated to develop vaccines capable of driving cellular immunity. T-cell epitope discovery is central to this concept. In this review, the significance of T-cell epitope-based vaccines for prophylactic and therapeutic applications is discussed. Additionally, methodologies for the discovery of T-cell epitopes, as well as recent developments in the clinical testing of these vaccines for various viral infections, are explained.

Keywords: MHC class I; cellular immunity; cytotoxic T cells; epitopes; humoral immunity; immunoproteomics; mass spectrometry; vaccine.

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Figures

Figure 1
Figure 1. Generation of adaptive immunity in infection and vaccine response
CTL: Cytotoxic T lymphocyte; IFN: Interferon.
See this image and copyright information in PMC

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