Regulation of PCNA-protein interactions for genome stability

doi:10.1038/nrm3562

Review

. 2013 May;14(5):269-82.

doi: 10.1038/nrm3562. Epub 2013 Apr 18.

Regulation of PCNA-protein interactions for genome stability

Niels Mailand¹, Ian Gibbs-Seymour, Simon Bekker-Jensen

Affiliations

Affiliation

¹ Ubiquitin Signaling Group, The Novo Nordisk Foundation Center for Protein Research, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen N, Denmark. niels.mailand@cpr.ku.dk

PMID: 23594953
DOI: 10.1038/nrm3562

Review

Regulation of PCNA-protein interactions for genome stability

Niels Mailand et al. Nat Rev Mol Cell Biol. 2013 May.

. 2013 May;14(5):269-82.

doi: 10.1038/nrm3562. Epub 2013 Apr 18.

Authors

Niels Mailand¹, Ian Gibbs-Seymour, Simon Bekker-Jensen

Affiliation

¹ Ubiquitin Signaling Group, The Novo Nordisk Foundation Center for Protein Research, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen N, Denmark. niels.mailand@cpr.ku.dk

PMID: 23594953
DOI: 10.1038/nrm3562

Abstract

Proliferating cell nuclear antigen (PCNA) has a central role in promoting faithful DNA replication, providing a molecular platform that facilitates the myriad protein-protein and protein-DNA interactions that occur at the replication fork. Numerous PCNA-associated proteins compete for binding to a common surface on PCNA; hence these interactions need to be tightly regulated and coordinated to ensure proper chromosome replication and integrity. Control of PCNA-protein interactions is multilayered and involves post-translational modifications, in particular ubiquitylation, accessory factors and regulated degradation of PCNA-associated proteins. This regulatory framework allows cells to maintain a fine-tuned balance between replication fidelity and processivity in response to DNA damage.

PubMed Disclaimer

Cited by

NKp44-Derived Peptide Used in Combination Stimulates Antineoplastic Efficacy of Targeted Therapeutic Drugs.
Iraqi M, Bolel P, Sarkar R, Bhattacharya B, Abu Ahmad M, Edri A, Roisman LC, Elkabets M, Shalata W, Peled N, Porgador A. Iraqi M, et al. Int J Mol Sci. 2022 Nov 14;23(22):14054. doi: 10.3390/ijms232214054. Int J Mol Sci. 2022. PMID: 36430528 Free PMC article.
Initiation and termination of DNA replication during S phase in relation to cyclins D1, E and A, p21WAF1, Cdt1 and the p12 subunit of DNA polymerase δ revealed in individual cells by cytometry.
Darzynkiewicz Z, Zhao H, Zhang S, Lee MY, Lee EY, Zhang Z. Darzynkiewicz Z, et al. Oncotarget. 2015 May 20;6(14):11735-50. doi: 10.18632/oncotarget.4149. Oncotarget. 2015. PMID: 26059433 Free PMC article. Review.
DEK oncoprotein participates in heterochromatin replication via SUMO-dependent nuclear bodies.
Pierzynska-Mach A, Czada C, Vogel C, Gwosch E, Osswald X, Bartoschek D, Diaspro A, Kappes F, Ferrando-May E. Pierzynska-Mach A, et al. J Cell Sci. 2023 Dec 1;136(23):jcs261329. doi: 10.1242/jcs.261329. Epub 2023 Dec 15. J Cell Sci. 2023. PMID: 37997922 Free PMC article.
Clinical Potential of Fruit in Bladder Cancer Prevention and Treatment.
Wigner P, Bijak M, Saluk-Bijak J. Wigner P, et al. Nutrients. 2022 Mar 8;14(6):1132. doi: 10.3390/nu14061132. Nutrients. 2022. PMID: 35334790 Free PMC article. Review.
PCNA-mediated stabilization of E3 ligase RFWD3 at the replication fork is essential for DNA replication.
Lin YC, Wang Y, Hsu R, Giri S, Wopat S, Arif MK, Chakraborty A, Prasanth KV, Prasanth SG. Lin YC, et al. Proc Natl Acad Sci U S A. 2018 Dec 26;115(52):13282-13287. doi: 10.1073/pnas.1814521115. Epub 2018 Dec 10. Proc Natl Acad Sci U S A. 2018. PMID: 30530694 Free PMC article.

See all "Cited by" articles

References

1. Proc Natl Acad Sci U S A. 2008 Mar 11;105(10):3768-73 - PubMed
1. Mol Cell. 2007 Dec 14;28(5):798-809 - PubMed
1. Structure. 2004 Dec;12(12):2209-19 - PubMed
1. Nucleic Acids Res. 2008 Dec;36(21):6767-80 - PubMed
1. Mol Cell. 2001 May;7(5):959-70 - PubMed

Publication types

Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions

Associated data

Actions
- Search in PubMed
- Search in Structure
Actions
- Search in PubMed
- Search in Structure
Actions
- Search in PubMed
- Search in Structure
Actions
- Search in PubMed
- Search in Structure
Actions
- Search in PubMed
- Search in Structure

LinkOut - more resources

Full Text Sources
- Nature Publishing Group
Other Literature Sources
- The Lens - Patent Citations Database
- scite Smart Citations
Miscellaneous
- NCI CPTAC Assay Portal

[1] Proc Natl Acad Sci U S A. 2008 Mar 11;105(10):3768-73 - PubMed

[2] Proc Natl Acad Sci U S A. 2008 Mar 11;105(10):3768-73 - PubMed

[3] Mol Cell. 2007 Dec 14;28(5):798-809 - PubMed

[4] Mol Cell. 2007 Dec 14;28(5):798-809 - PubMed

[5] Structure. 2004 Dec;12(12):2209-19 - PubMed

[6] Structure. 2004 Dec;12(12):2209-19 - PubMed

[7] Nucleic Acids Res. 2008 Dec;36(21):6767-80 - PubMed

[8] Nucleic Acids Res. 2008 Dec;36(21):6767-80 - PubMed

[9] Mol Cell. 2001 May;7(5):959-70 - PubMed

[10] Mol Cell. 2001 May;7(5):959-70 - PubMed

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Regulation of PCNA-protein interactions for genome stability

Affiliation

Regulation of PCNA-protein interactions for genome stability

Authors

Affiliation

Abstract

Similar articles

Cited by

References

Publication types

MeSH terms

Substances

Associated data

LinkOut - more resources

Full Text Sources

Other Literature Sources

Miscellaneous

Abstract

Similar articles

Cited by

References

Publication types

MeSH terms

Substances

Associated data

Related information

LinkOut - more resources

Full Text Sources

Other Literature Sources

Miscellaneous