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Review
. 2013 Jun;34(3):1895-9.
doi: 10.1007/s13277-013-0733-z. Epub 2013 Apr 16.

A systematic review of vascular endothelial growth factor expression as a biomarker of prognosis in patients with osteosarcoma

Ding Chen  1 , Ye-Jia Zhang, Ke-wei Zhu, Wan-Chun Wang
Affiliations
Review

A systematic review of vascular endothelial growth factor expression as a biomarker of prognosis in patients with osteosarcoma

Ding Chen et al. Tumour Biol. 2013 Jun.

Abstract

Vascular endothelial growth factor (VEGF) plays an important role in the tumor angiogenesis, and its expression has been supposed to be a biomarker of prognosis in patients with osteosarcoma. There are many studies assessing the prognostic role of VEGF expression in osteosarcoma, and no consistent outcomes are reported. To provide a comprehensive assessment of the prognostic role of VEGF expression, we performed a systematic review and meta-analysis of published studies. We assessed the effect of VEGF expression on the overall survival rate and the disease-free survival rate by calculating the pooled odds ratio (OR) with corresponding 95 % confidence interval (95 %CI). Finally, 12 studies with a total of 559 osteosarcoma patients were included into the systematic review and meta-analysis. Compared with osteosarcoma patients with low or negative VEGF expression, patients with high VEGF expression were obviously associated with lower disease-free survival (OR=0.25, 95 %CI 0.11-0.58, P=0.001, I (2) =56.4 %). In addition, patients with high VEGF expression were obviously associated with lower overall survival (OR=0.22, 95 %CI 0.13-0.35, P<0.001, I (2) =0.0 %). Therefore, the findings from this systematic review suggest that VEGF expression is an effective biomarker of prognosis in patients with osteosarcoma.

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