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Comparative Study
. 2013 Sep;20(9):2881-6.
doi: 10.1245/s10434-013-2961-2. Epub 2013 Apr 7.

Long-term outcomes comparing surgery to embolization-ablation for treatment of solitary HCC<7 cm

Eldad Elnekave  1 , Joseph P Erinjeri, Karen T Brown, Raymond H Thornton, Elena N Petre, Majid Maybody, Mary A Maluccio, Meier Hsu, Constantinos T Sofocleous, George I Getrajdman, Lynn A Brody, Stephen B Solomon, William Alago, Yuman Fong, William R Jarnagin, Anne M Covey
Affiliations
Comparative Study

Long-term outcomes comparing surgery to embolization-ablation for treatment of solitary HCC<7 cm

Eldad Elnekave et al. Ann Surg Oncol. 2013 Sep.

Abstract

Background: Resection has been the standard of care for patients with solitary hepatocellular carcinoma (HCC). Transarterial embolization and percutaneous ablation are alternative therapies often reserved for suboptimal surgical candidates. Here we compare long-term outcomes of patients with solitary HCC treated with resection versus combined embo-ablation.

Methods: We previously reported a retrospective comparison of resection and embo-ablation in 73 patients with solitary HCC<7 cm after a median follow-up of 23 months. This study represents long-term updated follow-up over a median of 134 months.

Results: There was no difference in survival among Okuda I patients who underwent resection versus embo-ablation (66 vs 58 months, p=.39). There was no difference between the groups in the rate of distant intrahepatic (p=.35) or metastatic progression (p=.48). Surgical patients experienced more complications (p=.004), longer hospitalizations (p<.001), and were more likely to require hospital readmission within 30 days of discharge (p=.03).

Conclusion: Over a median follow up of more than 10 years, we found no significant difference in overall survival of Okuda 1 patients with solitary HCC<7 cm who underwent surgical resection versus embo-ablation. Our data suggest that there may be a greater role for primary embo-ablation in the treatment of potentially resectable solitary HCC.

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Figures

FIG. 1
FIG. 1
Survival. Median follow-up was 134 months. a Overall survival by initial treatment. b Overall survival by treatment and Okuda stage. c Overall survival by Okuda stage
FIG. 2
FIG. 2
Disease recurrence. a Intrahepatic disease progression. b Extrahepatic disease progression
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References

    1. Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 2010;127:2893–917. - PubMed
    1. Alter MJ. Hepatitis C virus infection in the United States. J Hepatol 1999;31 Suppl 1:88–91. - PubMed
    1. Fattovich G, Stroffolini T, Zagni I, Donato F. Hepatocellular carcinoma in cirrhosis: incidence and risk factors. Gastroenterology 2004;127:S35–50. - PubMed
    1. Davila JA, Morgan RO, Shaib Y, McGlynn KA, El-Serag HB. Hepatitis C infection and the increasing incidence of hepatocellular carcinoma: a population-based study. Gastroenterology 2004;127:1372–80. - PubMed
    1. El-Serag HB. Hepatocellular carcinoma. N Engl J Med 2011;365:1118–27. - PubMed

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