Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2011 May 1;7(3):e60-e76.
doi: 10.1016/j.jalz.2011.05.001.

Assessment of cognition in early dementia

Nina B Silverberg  1 , Laurie M Ryan, Maria C Carrillo, Reisa Sperling, Ronald C Petersen, Holly B Posner, Peter J Snyder, Robin Hilsabeck, Michela Gallagher, Jacob Raber, Albert Rizzo, Katherine Possin, Jonathan King, Jeffrey Kaye, Brian R Ott, Marilyn S Albert, Molly V Wagster, John A Schinka, C Munro Cullum, Sarah T Farias, David Balota, Stephen Rao, David Loewenstein, Andrew E Budson, Jason Brandt, Jennifer J Manly, Lisa Barnes, Adriana Strutt, Tamar H Gollan, Mary Ganguli, Debra Babcock, Irene Litvan, Joel H Kramer, Tanis J Ferman
Affiliations

Assessment of cognition in early dementia

Nina B Silverberg et al. Alzheimers Dement. .

Abstract

Better tools for assessing cognitive impairment in the early stages of Alzheimer's disease (AD) are required to enable diagnosis of the disease before substantial neurodegeneration has taken place and to allow detection of subtle changes in the early stages of progression of the disease. The National Institute on Aging and the Alzheimer's Association convened a meeting to discuss state of the art methods for cognitive assessment, including computerized batteries, as well as new approaches in the pipeline. Speakers described research using novel tests of object recognition, spatial navigation, attentional control, semantic memory, semantic interference, prospective memory, false memory and executive function as among the tools that could provide earlier identification of individuals with AD. In addition to early detection, there is a need for assessments that reflect real-world situations in order to better assess functional disability. It is especially important to develop assessment tools that are useful in ethnically, culturally and linguistically diverse populations as well as in individuals with neurodegenerative disease other than AD.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. NINDS. NINDS Common Data Elements. 2010 [cited; Available from: http://www.commondataelements.ninds.nih.gov/default.aspx.
    2. Jack A. Clifford R., Albert Marilyn, Knopman David S., McKhann Guy M., Sperling Reisa A., Carrillo Maria C., Thies Bill, Phelps Creighton H. Introduction to revised criteria for the diagnosis of Alzheimer’s disease: National Institute on Aging and the Alzheimer's Association workgroup. Alzheimer's & Dementia: The Journal of the Alzheimer's Association. 2011 Apr 22; - PMC - PubMed
    3. McKhann Guy M., Knopman David S., Chertkow Howard, Hyman Bradley T., Jack Clifford R., Kawas Claudia H., Klunk William E., Koroshetz Walter J., Manly Jennifer J., Mayeux Richard, Mohs Richard C., Morris John C., Rossor Martin N., Scheltens Philip, Carillo Maria C., Thies Bill, Weintraub Sandra, Phelps Creighton H. The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging and the Alzheimer’s Association workgroup. Alzheimer's & Dementia: The Journal of the Alzheimer's Association. 2011 Apr 22; - PMC - PubMed
    4. Albert Marilyn S., DeKosky Steven T., Dickson Dennis, Dubois Bruno, Feldman Howard H., Fox Nick C., Gamst Anthony, Holtzman David M., Jagust William J., Petersen Ronald C., Snyder Peter J., Carrillo Maria C., Thies Bill, Phelps Creighton H. The diagnosis of mild cognitive impairment due to Alzheimer’s disease: Recommendations from the National Institute on Aging and Alzheimer’s Association workgrou. Alzheimer's & Dementia: The Journal of the Alzheimer's Association. 2011 Apr 22; - PMC - PubMed
    5. Sperling Reisa A., Aisen Paul S., Beckett Laurel A., Bennett David A., Craft Suzanne, Fagan Anne M., Iwatsubo Takeshi, Jack Clifford R., Kaye Jeffrey, Montine Thomas J., Park Denise C., Reiman Eric M., Rowe Christopher C., Siemers Eric, Stern Yaakov, Yaffe Kristine, Carrillo Maria C., Thies Bill, Morrison-Bogorad Marcelle, Wagster Molly V., Phelps Creighton H. Toward defining the preclinical stages of Alzheimer’s disease: Recommendations from the National Institute on Aging and the Alzheimer's Association workgroup. Alzheimer's & Dementia: The Journal of the Alzheimer's Association. 2011 Apr 22; - PMC - PubMed
    6. B. American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 4th ed. Washington, DC: 2000. text rev.
    1. Seeley WW, et al. Neurodegenerative diseases target large-scale human brain networks. Neuron. 2009;62(1):42–52. - PMC - PubMed
    1. Sperling RA, et al. Functional alterations in memory networks in early Alzheimer's disease. Neuromolecular Med. 2010;12(1):27–43. - PMC - PubMed
    1. Celone KA, et al. Alterations in memory networks in mild cognitive impairment and Alzheimer's disease: an independent component analysis. J Neurosci. 2006;26(40):10222–10231. - PMC - PubMed
    1. Vannini P, et al. What Goes Down Must Come Up: Role of the Posteromedial Cortices in Encoding and Retrieval. Cereb Cortex. 2010 - PMC - PubMed