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. 2013 Apr 4:11:28.
doi: 10.1186/1477-7827-11-28.

Does hormonal contraception prior to in vitro fertilization (IVF) negatively affect oocyte yields? A pilot study

David H Barad  1 , Ann Kim, Hala Kubba, Andrea Weghofer, Norbert Gleicher
Affiliations

Does hormonal contraception prior to in vitro fertilization (IVF) negatively affect oocyte yields? A pilot study

David H Barad et al. Reprod Biol Endocrinol. .

Abstract

Background: As oral contraceptives (OCs) suppress anti-Müllerian hormone (AMH), and hormonal contraceptives (HCs), likely, suppress functional ovarian reserve, this study was initiated to determine whether HC affect oocyte yields.

Methods: We investigated in a retrospective cohort study 43 oocyte donors in 71 in vitro fertilization (IVF) cycles, evaluating anti-Müllerian hormone (AMH) and oocyte yields as reflections of functional ovarian reserve (OR). In 25 IVF cycles egg donors were on HC within one month prior to IVF, and in 46 cycles they were not. Donors, based on their HCs, were further subdivided into 12 with less, and 13 with more androgenic progestins.

Results: While the three groups did not differ in age, age at menarche, BMI and AMH, oocyte yields among donors who utilized estrane- and gonane-derived (higher androgenic) HCs were lower 11.3 (95% CI 8.3 - 14.3) than either donors using no HCs 16.6 (95% CI 14.7 -18.4) (P < 0.05) or those using anti-androgenic HCs 19.0 (95% CI 12.2-25.8) (P< 0.01). Significance was maintained after adjustments for the donor age and total FSH dose used in ovulation induction.

Conclusions: Even in young oocyte donors, high androgenic OC exposure appears to suppress functional ovarian reserve and oocyte yields. Since OCs are often routinely used in preparation for IVF, such practice may require reevaluation. Especially in women with diminished ovarian reserve OCs, and especially high androgenic progestin HCs, should, likely, be avoided.

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Figures

Figure 1
Figure 1
Oocyte yields of women using androgenic hormonal contraception. Oocyte yields of women using androgenic hormonal contraception were significantly lower than either women using no contraception or those using anti-androgenic contraceptives.
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References

    1. Ferraretti AP, La Marca A, Fauser BC, Tarlatzis B, Nargund G, Gianaroli L. ESHRE consensus on the definition of 'poor response' to ovarian stimulation for in vitro fertilization: the Bologna criteria. Hum Reprod. 2011;26:1616–1624. doi: 10.1093/humrep/der092. - DOI - PubMed
    1. Surrey ES. Management of the poor responder: the role of GnRH agonists and antagonists. J Assist Reprod Genet. 2007;24:613–619. doi: 10.1007/s10815-007-9180-3. - DOI - PMC - PubMed
    1. Lindheim SR, Barad DH, Witt B, Ditkoff E, Sauer MV. Short-term gonadotropin suppression with oral contraceptives benefits poor responders prior to controlled ovarian hyperstimulation. J Assist Reprod Genet. 1996;13:745–747. doi: 10.1007/BF02066431. - DOI - PubMed
    1. Fisch B, Royburt M, Pinkas H, Avrech OM, Goldman GA, Bar J, Tadir Y, Ovadia J. Augmentation of low ovarian response to superovulation before in vitro fertilization following priming with contraceptive pills. Isr J Med Sci. 1996;32:1172–1176. - PubMed
    1. Biljan MM, Mahutte NG, Dean N, Hemmings R, Bissonnette F, Tan SL. Pretreatment with an oral contraceptive is effective in reducing the incidence of functional ovarian cyst formation during pituitary suppression by gonadotropin-releasing hormone analogues. J Assist Reprod Genet. 1998;15:599–604. doi: 10.1023/A:1020381310860. - DOI - PMC - PubMed

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