Generators of phenotypic diversity in the evolution of pathogenic microorganisms

doi:10.1371/journal.ppat.1003181

. 2013 Mar;9(3):e1003181.

doi: 10.1371/journal.ppat.1003181. Epub 2013 Mar 21.

Generators of phenotypic diversity in the evolution of pathogenic microorganisms

Silvia Calo¹, R Blake Billmyre, Joseph Heitman

Affiliations

PMID: 23555239
PMCID: PMC3605297
DOI: 10.1371/journal.ppat.1003181

Generators of phenotypic diversity in the evolution of pathogenic microorganisms

Silvia Calo et al. PLoS Pathog. 2013 Mar.

. 2013 Mar;9(3):e1003181.

doi: 10.1371/journal.ppat.1003181. Epub 2013 Mar 21.

Authors

Silvia Calo¹, R Blake Billmyre, Joseph Heitman

Affiliation

¹ Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America.

PMID: 23555239
PMCID: PMC3605297
DOI: 10.1371/journal.ppat.1003181

No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

**Figure 1. Generators of phenotypic diversity illustrated as a game of chance.**
Evolution is a multifactorial process that depends on numerous complex factors, including routes to diversity that can be deleterious, neutral, or advantageous depending on the environment. Here we depict these evolutionary trajectories using the analogy of a roulette wheel in which one possible path yields a winner that develops a new trait that allows the microorganism to survive in novel conditions, such as a host treated with antimicrobial agents. However, as in roulette, the odds are against the gambler and the other routes and outcomes are deleterious.

See this image and copyright information in PMC

Cited by

How often do they have sex? A comparative analysis of the population structure of seven eukaryotic microbial pathogens.
Tomasini N, Lauthier JJ, Ayala FJ, Tibayrenc M, Diosque P. Tomasini N, et al. PLoS One. 2014 Jul 23;9(7):e103131. doi: 10.1371/journal.pone.0103131. eCollection 2014. PLoS One. 2014. PMID: 25054834 Free PMC article.
Population Genetics of Hirsutella rhossiliensis, a Dominant Parasite of Cyst Nematode Juveniles on a Continental Scale.
Wang N, Zhang Y, Jiang X, Shu C, Hamid MI, Hussain M, Chen S, Xu J, Xiang M, Liu X. Wang N, et al. Appl Environ Microbiol. 2016 Oct 14;82(21):6317-6325. doi: 10.1128/AEM.01708-16. Print 2016 Nov 1. Appl Environ Microbiol. 2016. PMID: 27542936 Free PMC article.
Stochastic developmental variation, an epigenetic source of phenotypic diversity with far-reaching biological consequences.
Vogt G. Vogt G. J Biosci. 2015 Mar;40(1):159-204. doi: 10.1007/s12038-015-9506-8. J Biosci. 2015. PMID: 25740150 Review.
Parasexual Ploidy Reduction Drives Population Heterogeneity Through Random and Transient Aneuploidy in Candida albicans.
Hickman MA, Paulson C, Dudley A, Berman J. Hickman MA, et al. Genetics. 2015 Jul;200(3):781-94. doi: 10.1534/genetics.115.178020. Epub 2015 May 18. Genetics. 2015. PMID: 25991822 Free PMC article.
Cryptosporidium,Giardia, Cryptococcus, Pneumocystis genetic variability: cryptic biological species or clonal near-clades?
Tibayrenc M, Ayala FJ. Tibayrenc M, et al. PLoS Pathog. 2014 Apr 10;10(4):e1003908. doi: 10.1371/journal.ppat.1003908. eCollection 2014 Apr. PLoS Pathog. 2014. PMID: 24722548 Free PMC article. Review.

See all "Cited by" articles

References

1. Rutherford SL, Lindquist S (1998) Hsp90 as a capacitor for morphological evolution. Nature 396: 336–342. - PubMed
1. Queitsch C, Sangster TA, Lindquist S (2002) Hsp90 as a capacitor of phenotypic variation. Nature 417: 618–624. - PubMed
1. Tibayrenc M, Kjellberg F, Arnaud J, Oury B, Brenière SF, et al. (1991) Are eukaryotic microorganisms clonal or sexual? A population genetics vantage. Proc Natl Acad Sci U S A 88: 5129–5133. - PMC - PubMed
1. Tibayrenc M, Kjellberg F, Ayala FJ (1990) A clonal theory of parasitic protozoa: the population structures of Entamoeba, Giardia, Leishmania, Naegleria, Plasmodium, Trichomonas, and Trypanosoma and their medical and taxonomical consequences. Proc Natl Acad Sci U S A 87: 2414–2418. - PMC - PubMed
1. Heitman J (2006) Sexual reproduction and the evolution of microbial pathogens. Curr Biol 16: R711–725. - PubMed

Publication types

Actions

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources
Other Literature Sources
- The Lens - Patent Citations Database
- scite Smart Citations
Medical
- MedlinePlus Health Information

[1] Rutherford SL, Lindquist S (1998) Hsp90 as a capacitor for morphological evolution. Nature 396: 336–342. - PubMed

[2] Rutherford SL, Lindquist S (1998) Hsp90 as a capacitor for morphological evolution. Nature 396: 336–342. - PubMed

[3] Queitsch C, Sangster TA, Lindquist S (2002) Hsp90 as a capacitor of phenotypic variation. Nature 417: 618–624. - PubMed

[4] Queitsch C, Sangster TA, Lindquist S (2002) Hsp90 as a capacitor of phenotypic variation. Nature 417: 618–624. - PubMed

[5] Tibayrenc M, Kjellberg F, Arnaud J, Oury B, Brenière SF, et al. (1991) Are eukaryotic microorganisms clonal or sexual? A population genetics vantage. Proc Natl Acad Sci U S A 88: 5129–5133. - PMC - PubMed

[6] Tibayrenc M, Kjellberg F, Arnaud J, Oury B, Brenière SF, et al. (1991) Are eukaryotic microorganisms clonal or sexual? A population genetics vantage. Proc Natl Acad Sci U S A 88: 5129–5133. - PMC - PubMed

[7] Tibayrenc M, Kjellberg F, Ayala FJ (1990) A clonal theory of parasitic protozoa: the population structures of Entamoeba, Giardia, Leishmania, Naegleria, Plasmodium, Trichomonas, and Trypanosoma and their medical and taxonomical consequences. Proc Natl Acad Sci U S A 87: 2414–2418. - PMC - PubMed

[8] Tibayrenc M, Kjellberg F, Ayala FJ (1990) A clonal theory of parasitic protozoa: the population structures of Entamoeba, Giardia, Leishmania, Naegleria, Plasmodium, Trichomonas, and Trypanosoma and their medical and taxonomical consequences. Proc Natl Acad Sci U S A 87: 2414–2418. - PMC - PubMed

[9] Heitman J (2006) Sexual reproduction and the evolution of microbial pathogens. Curr Biol 16: R711–725. - PubMed

[10] Heitman J (2006) Sexual reproduction and the evolution of microbial pathogens. Curr Biol 16: R711–725. - PubMed

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Generators of phenotypic diversity in the evolution of pathogenic microorganisms

Affiliation

Generators of phenotypic diversity in the evolution of pathogenic microorganisms

Authors

Affiliation

Conflict of interest statement

Figures

Similar articles

Cited by

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical