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. 2013 Jul 1;63(3):367-71.
doi: 10.1097/QAI.0b013e3182910121.

Circulating levels of tissue factor microparticle procoagulant activity are reduced with antiretroviral therapy and are associated with persistent inflammation and coagulation activation among HIV-positive patients

Jason V Baker  1 , Katherine Huppler Hullsiek, Robert L Bradford, Rachel Prosser, Russell P Tracy, Nigel S Key
Affiliations

Circulating levels of tissue factor microparticle procoagulant activity are reduced with antiretroviral therapy and are associated with persistent inflammation and coagulation activation among HIV-positive patients

Jason V Baker et al. J Acquir Immune Defic Syndr. .

Abstract

Activation of coagulation pathways may contribute to risk for non-AIDS-related conditions among HIV-positive patients. Tissue factor (TF)-dependent procoagulant activity on circulating microparticles (MP-TF) in the plasma of 163 HIV-positive participants, both untreated and treated, with viral suppression was measured. MP-TF activity was 39% lower among treated versus untreated participants (P < 0.001), which persisted in adjusted models (-36%, P = 0.03). Among treated participants, MP-TF activity correlated modestly with D-dimer (r = 0.24, P = 0.01), von Willebrand factor (r = 0.36, P < 0.001), and interleukin-6 (r = 0.20, P = 0.04) levels. Future research should focus on mechanisms driving residual functional TF activity and whether these alterations have clinical consequences for non-AIDS-defining complications.

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Conflict of interest statement

Conflicts of Interest: None reported.

Figures

Figure 1
Figure 1. Correlations Between MP-TF Activity and Plasma Biomarker Levels
Legend: Scatter plot with trend line describes the correlation between MP-TF activity and D-dimer (a; square), vWF (b; triangle), IL-6 (c; circle) and hsCRP (d; diamond) levels. Spearman’s rank correlation coefficient and p-value are reported.
See this image and copyright information in PMC

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