The regulatory roles of phosphatases in cancer
- PMID: 23503460
- DOI: 10.1038/onc.2013.80
The regulatory roles of phosphatases in cancer
Abstract
The relevance of potentially reversible post-translational modifications required for controlling cellular processes in cancer is one of the most thriving arenas of cellular and molecular biology. Any alteration in the balanced equilibrium between kinases and phosphatases may result in development and progression of various diseases, including different types of cancer, though phosphatases are relatively under-studied. Loss of phosphatases such as PTEN (phosphatase and tensin homologue deleted on chromosome 10), a known tumour suppressor, across tumour types lends credence to the development of phosphatidylinositol 3-kinase inhibitors alongside the use of phosphatase expression as a biomarker, though phase 3 trial data are lacking. In this review, we give an updated report on phosphatase dysregulation linked to organ-specific malignancies.
Similar articles
-
The emerging roles of dual-specificity phosphatases and their specific characteristics in human cancer.Biochim Biophys Acta Rev Cancer. 2021 Aug;1876(1):188562. doi: 10.1016/j.bbcan.2021.188562. Epub 2021 May 5. Biochim Biophys Acta Rev Cancer. 2021. PMID: 33964330 Review.
-
Phosphatases and tumorigenesis.Curr Opin Oncol. 1998 Jan;10(1):88-91. doi: 10.1097/00001622-199801000-00014. Curr Opin Oncol. 1998. PMID: 9466490 Review.
-
The INPP4B paradox: Like PTEN, but different.Adv Biol Regul. 2021 Dec;82:100817. doi: 10.1016/j.jbior.2021.100817. Epub 2021 Jun 16. Adv Biol Regul. 2021. PMID: 34216856 Review.
-
Suppression of survival signalling pathways by the phosphatase PHLPP.FEBS J. 2013 Jan;280(2):572-83. doi: 10.1111/j.1742-4658.2012.08537.x. Epub 2012 Mar 16. FEBS J. 2013. PMID: 22340730 Free PMC article.
-
Regulatory cascades of protein phosphatases: implications for cancer treatment.Anticancer Agents Med Chem. 2011 Jan;11(1):64-77. doi: 10.2174/187152011794941253. Anticancer Agents Med Chem. 2011. PMID: 21214508 Review.
Cited by
-
The phosphatase CTDSPL2 is phosphorylated in mitosis and a target for restraining tumor growth and motility in pancreatic cancer.Cancer Lett. 2022 Feb 1;526:53-65. doi: 10.1016/j.canlet.2021.11.018. Epub 2021 Nov 20. Cancer Lett. 2022. PMID: 34813892 Free PMC article.
-
Discriminating between competing models for the allosteric regulation of oncogenic phosphatase SHP2 by characterizing its active state.Comput Struct Biotechnol J. 2021 Nov 3;19:6125-6139. doi: 10.1016/j.csbj.2021.10.041. eCollection 2021. Comput Struct Biotechnol J. 2021. PMID: 34900129 Free PMC article.
-
Recent development of near-infrared photoacoustic probes based on small-molecule organic dye.RSC Chem Biol. 2021 Mar 24;2(3):743-758. doi: 10.1039/d0cb00225a. eCollection 2021 Jun 1. RSC Chem Biol. 2021. PMID: 34458809 Free PMC article. Review.
-
Protein Phosphatases Involved in Regulating Mitosis: Facts and Hypotheses.Mol Cells. 2016 Sep;39(9):654-62. doi: 10.14348/molcells.2016.0214. Epub 2016 Sep 27. Mol Cells. 2016. PMID: 27669825 Free PMC article. Review.
-
Identification of key gene signatures for the overall survival of ovarian cancer.J Ovarian Res. 2022 Jan 20;15(1):12. doi: 10.1186/s13048-022-00942-0. J Ovarian Res. 2022. PMID: 35057823 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Research Materials
