Intrinsic antibiotic resistance: mechanisms, origins, challenges and solutions
- PMID: 23499305
- DOI: 10.1016/j.ijmm.2013.02.009
Intrinsic antibiotic resistance: mechanisms, origins, challenges and solutions
Abstract
The intrinsic antibiotic resistome is a naturally occurring phenomenon that predates antibiotic chemotherapy and is present in all bacterial species. In addition to the intrinsic resistance mediated by the bacterial outer membrane and active efflux, studies have shown that a surprising number of additional genes and genetic loci also contribute to this phenotype. Antibiotic resistance is rife in both the clinic and the environment; novel therapeutic strategies need to be developed in order to prevent a major global clinical threat. The possibility of inhibiting elements comprising the intrinsic resistome in bacterial pathogens offers the promise for repurposing existing antibiotics against intrinsically resistant bacteria.
Keywords: Adjuvant; Antibiotic resistance; Efflux; Gram-negative pathogens; Intrinsic antibiotic resistance; Outer membrane; Permeability; Potentiate; Resistome.
Copyright © 2013 Elsevier GmbH. All rights reserved.
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