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Review
. 2013 Apr;8(4):361-72.
doi: 10.4161/epi.24234. Epub 2013 Mar 11.

Transcriptional regulation by the Set7 lysine methyltransferase

Samuel T Keating  1 , Assam El-Osta  2
Affiliations
Review

Transcriptional regulation by the Set7 lysine methyltransferase

Samuel T Keating et al. Epigenetics. 2013 Apr.

Abstract

Posttranslational histone modifications define chromatin structure and function. In recent years, a number of studies have characterized many of the enzymatic activities and diverse regulatory components required for monomethylation of histone H3 lysine 4 (H3K4me1) and the expression of specific genes. The challenge now is to understand how this specific chemical modification is written and the Set7 methyltransferase has emerged as a key regulatory enzyme mediating methylation of lysine residues of histone and non-histone proteins. In this review, we comprehensively explore the regulatory proteins modified by Set7 and highlight mechanisms of specific co-recruitment of the enzyme to activating promoters. With a focus on signaling and transcriptional control in disease we discuss recent experimental data emphasizing specific components of diverse regulatory complexes that mediate chromatin modification and reinterpretation of Set7-mediated gene expression.

Keywords: Set7; Set9; chromatin; epigenetics; gene expression; histone modification; lysine methylation; metabolic memory; p65.

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Figures

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Figure 1. Wordcloud depiction of transcriptional changes exhibited by human microvascular endothelial cells depleted of Set7. According to mRNA sequencing, gene symbols in the upper panel were upregulated and gene symbols in the lower panel were downregulated compared with control samples. The size of the gene symbol indicates relative p value strength.
See this image and copyright information in PMC

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References

    1. Bird A. Perceptions of epigenetics. Nature. 2007;447:396–8. doi: 10.1038/nature05913. - DOI - PubMed
    1. Strahl BD, Allis CD. The language of covalent histone modifications. Nature. 2000;403:41–5. doi: 10.1038/47412. - DOI - PubMed
    1. Turner BM. Histone acetylation and an epigenetic code. Bioessays. 2000;22:836–45. doi: 10.1002/1521-1878(200009)22:9<836::AID-BIES9>3.0.CO;2-X. - DOI - PubMed
    1. Jenuwein T, Allis CD. Translating the histone code. Science. 2001;293:1074–80. doi: 10.1126/science.1063127. - DOI - PubMed
    1. Dai Z, Dai X, Xiang Q, Feng J, Wang J, Deng Y, et al. Genome-wide analysis of interactions between ATP-dependent chromatin remodeling and histone modifications. BMC Genomics. 2009;10:304. doi: 10.1186/1471-2164-10-304. - DOI - PMC - PubMed

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