The role of inflammation in age-related disease
- PMID: 23474627
- PMCID: PMC3616233
- DOI: 10.18632/aging.100531
The role of inflammation in age-related disease
Abstract
The National Institutes of Health (NIH) Geroscience Interest Group (GSIG) sponsored workshop, The Role of Inflammation inAge-Related Disease, was held September 6th-7th, 2012 in Bethesda, MD. It is now recognized that a mild pro-inflammatory state is correlated with the major degenerative diseases of the elderly. The focus of the workshop was to better understand the origins and consequences of this low level chronic inflammation in order to design appropriate interventional studies aimed at improving healthspan. Four sessions explored the intrinsic, environmental exposures and immune pathways by which chronic inflammation are generated, sustained, and lead to age-associated diseases. At the conclusion of the workshop recommendations to accelerate progress toward understanding the mechanistic bases of chronic disease were identified.
Similar articles
-
Geroscience and the trans-NIH Geroscience Interest Group, GSIG.Geroscience. 2017 Feb;39(1):1-5. doi: 10.1007/s11357-016-9954-6. Geroscience. 2017. PMID: 28299635 Free PMC article.
-
Innate immunity and cellular senescence: The good and the bad in the developmental and aged brain.J Leukoc Biol. 2018 Mar;103(3):509-524. doi: 10.1002/JLB.3MR0118-003R. Epub 2018 Feb 1. J Leukoc Biol. 2018. PMID: 29389023 Review.
-
Reverse geroscience: how does exposure to early diseases accelerate the age-related decline in health?Ann N Y Acad Sci. 2016 Dec;1386(1):30-44. doi: 10.1111/nyas.13297. Epub 2016 Dec 1. Ann N Y Acad Sci. 2016. PMID: 27907230 Review.
-
Senolytics and senomorphics: Natural and synthetic therapeutics in the treatment of aging and chronic diseases.Free Radic Biol Med. 2021 Aug 1;171:169-190. doi: 10.1016/j.freeradbiomed.2021.05.003. Epub 2021 May 12. Free Radic Biol Med. 2021. PMID: 33989756 Review.
-
The integration of inflammaging in age-related diseases.Semin Immunol. 2018 Dec;40:17-35. doi: 10.1016/j.smim.2018.09.003. Epub 2018 Oct 2. Semin Immunol. 2018. PMID: 30287177 Review.
Cited by
-
p47phox-Nox2-dependent ROS Signaling Inhibits Early Bone Development in Mice but Protects against Skeletal Aging.J Biol Chem. 2015 Jun 5;290(23):14692-704. doi: 10.1074/jbc.M114.633461. Epub 2015 Apr 28. J Biol Chem. 2015. PMID: 25922068 Free PMC article.
-
Amyloid β: one of three danger-associated molecules that are secondary inducers of the proinflammatory cytokines that mediate Alzheimer's disease.Br J Pharmacol. 2015 Aug;172(15):3714-27. doi: 10.1111/bph.13181. Epub 2015 Jun 29. Br J Pharmacol. 2015. PMID: 25939581 Free PMC article. Review.
-
Aging alone or combined with obesity increases white adipose tissue inflammatory status in male mice.Sci Rep. 2024 Jul 15;14(1):16268. doi: 10.1038/s41598-024-67179-3. Sci Rep. 2024. PMID: 39009694 Free PMC article.
-
Aging of mice is associated with p16(Ink4a)- and β-galactosidase-positive macrophage accumulation that can be induced in young mice by senescent cells.Aging (Albany NY). 2016 Jul;8(7):1294-315. doi: 10.18632/aging.100991. Aging (Albany NY). 2016. PMID: 27391570 Free PMC article.
-
Vascular Inflammation and Oxidative Stress: Major Triggers for Cardiovascular Disease.Oxid Med Cell Longev. 2019 Jun 23;2019:7092151. doi: 10.1155/2019/7092151. eCollection 2019. Oxid Med Cell Longev. 2019. PMID: 31341533 Free PMC article. Review.
Publication types
MeSH terms
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
