doi: 10.1016/j.carres.2012.12.022.
Epub 2013 Jan 9.
Cholestane steroid glycosides from the rhizomes of Dioscorea villosa (wild yam)
Affiliations
- PMID: 23454141
- PMCID: PMC4009708
- DOI: 10.1016/j.carres.2012.12.022
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Cholestane steroid glycosides from the rhizomes of Dioscorea villosa (wild yam)
Carbohydr Res.
.
Abstract
Phytochemical investigation of the MeOH extract of Dioscorea villosa rhizomes resulted in the isolation of two new bidesmosidic cholestane steroid glycosides, dioscoreavillosides A and B (1 and 2). In addition, the extract yielded 12 previously known furostan and spirostan steroid glycosides (3-14), along with diosgenin (15). Compounds 3-7, 9, 14, and 15 were isolated for the first time from D. villosa. The structures of the isolated compounds were determined using spectroscopic and chemical methods including 1D and 2D NMR. The antimicrobial action of most of these compounds was tested against five fungal and five bacterial strains.
Copyright © 2013 Elsevier Ltd. All rights reserved.
Figures
The structures of compounds 1–15.
Key HMBC correlations of 1 and 2.
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References
-
- Hu CC, Lin JT, Liu SC, Yang DJ. J Food Drug Anal. 2007;15:310–315.
-
- Liu XT, Wang ZZ, Xiao W, Zhao HW, Hu J, Yu B. Phytochemistry. 2008;69:1411–1418. - PubMed
-
- Shen P, Wang SL, Liu XK, Yang CR, Cai B, Yao XS. J Asian Nat Prod, Res. 2002;4:211–215. - PubMed
-
- Yin J, Kouda K, Tezuka Y, Tran QL, Miyahara T, Chen Y, Kadota S. J Nat Prod. 2003;66:646–650. - PubMed
-
- Teponno RB, Tapondjou AL, Abou-Mansour E, Stoeckli-Evans H, Tane P, Barboni L. Phytochemistry. 2008;69:2374–2379.
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