An unusual case report on the possible role of Warfarin in migraine prophylaxis

doi:10.1186/2193-1801-2-48

Case Reports

. 2013 Dec;2(1):48.

doi: 10.1186/2193-1801-2-48. Epub 2013 Feb 12.

An unusual case report on the possible role of Warfarin in migraine prophylaxis

Angelo Russo¹, Sara Santi, Daniela Gueraldi, Maria De Paola, Fabiana Zani, Luigi Alberto Pini

Affiliations

PMID: 23450798
PMCID: PMC3579414
DOI: 10.1186/2193-1801-2-48

Case Reports

An unusual case report on the possible role of Warfarin in migraine prophylaxis

Angelo Russo et al. Springerplus. 2013 Dec.

. 2013 Dec;2(1):48.

doi: 10.1186/2193-1801-2-48. Epub 2013 Feb 12.

Authors

Angelo Russo¹, Sara Santi, Daniela Gueraldi, Maria De Paola, Fabiana Zani, Luigi Alberto Pini

Affiliation

¹ Pediatric Neurology Unit, Modena and Reggio Emilia University, Modena, 41124 Italy.

PMID: 23450798
PMCID: PMC3579414
DOI: 10.1186/2193-1801-2-48

Abstract

Background: Migraine is a complex disease whose physiopathological mechanisms are still not completely revealed.

Findings: We describe an unusual case, not yet described in literature, of a patient who reported migraine remission, but still presented aura attacks, since starting a therapy with Warfarin.

Conclusions: This case report brings out new questions on the role of the coagulation, especially the blood coagulation pathway, in migraine with aura pathogenesis, and on the possibility to use vitamin K synthesis inhibitors, Warfarin or new generation drugs, as possible therapy to use in migraine prophylaxis.

Keywords: Anticoagulant drugs; Aura; Coagulation; Migraine.

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References

1. Ahrens I, Lip GYH, Peter K. New oral anticoagulant drugs in cardiovascular disease. Thromb Haemost. 2010;104:49–60. doi: 10.1160/TH09-05-0327. - DOI - PubMed
1. Corral J, Iniesta JA, Gonzalez-Conejero R, Lozano ML, et al. Migraine and prothrombotic genetic risk factors. Cephalalgia. 1998;18(5):257–260. doi: 10.1046/j.1468-2982.1998.1805257.x. - DOI - PubMed
1. Edvinsson L, Uddman R. Neurobiology in primary headaches. Brain Res Rev. 2005;48(3):438–456. doi: 10.1016/j.brainresrev.2004.09.007. - DOI - PubMed
1. Hering-Hanit R, Friedman Z, Schlesinger I, Ellis M. Evidence for activation of the coagulation system in migraine with aura. Cephalalgia. 2001;21(2):137–139. doi: 10.1046/j.1468-2982.2001.00181.x. - DOI - PubMed
1. Maggioni F, Bruno M, Mainardi F, Lisotto C, et al. Migraine responsive to warfarin: an update on anticoagulant possible role in migraine prophylaxis. Neurol Sci. 2012;33(6):1447–1449. doi: 10.1007/s10072-011-0926-4. - DOI - PubMed

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[1] Ahrens I, Lip GYH, Peter K. New oral anticoagulant drugs in cardiovascular disease. Thromb Haemost. 2010;104:49–60. doi: 10.1160/TH09-05-0327. - DOI - PubMed

[2] Ahrens I, Lip GYH, Peter K. New oral anticoagulant drugs in cardiovascular disease. Thromb Haemost. 2010;104:49–60. doi: 10.1160/TH09-05-0327. - DOI - PubMed

[3] Corral J, Iniesta JA, Gonzalez-Conejero R, Lozano ML, et al. Migraine and prothrombotic genetic risk factors. Cephalalgia. 1998;18(5):257–260. doi: 10.1046/j.1468-2982.1998.1805257.x. - DOI - PubMed

[4] Corral J, Iniesta JA, Gonzalez-Conejero R, Lozano ML, et al. Migraine and prothrombotic genetic risk factors. Cephalalgia. 1998;18(5):257–260. doi: 10.1046/j.1468-2982.1998.1805257.x. - DOI - PubMed

[5] Edvinsson L, Uddman R. Neurobiology in primary headaches. Brain Res Rev. 2005;48(3):438–456. doi: 10.1016/j.brainresrev.2004.09.007. - DOI - PubMed

[6] Edvinsson L, Uddman R. Neurobiology in primary headaches. Brain Res Rev. 2005;48(3):438–456. doi: 10.1016/j.brainresrev.2004.09.007. - DOI - PubMed

[7] Hering-Hanit R, Friedman Z, Schlesinger I, Ellis M. Evidence for activation of the coagulation system in migraine with aura. Cephalalgia. 2001;21(2):137–139. doi: 10.1046/j.1468-2982.2001.00181.x. - DOI - PubMed

[8] Hering-Hanit R, Friedman Z, Schlesinger I, Ellis M. Evidence for activation of the coagulation system in migraine with aura. Cephalalgia. 2001;21(2):137–139. doi: 10.1046/j.1468-2982.2001.00181.x. - DOI - PubMed

[9] Maggioni F, Bruno M, Mainardi F, Lisotto C, et al. Migraine responsive to warfarin: an update on anticoagulant possible role in migraine prophylaxis. Neurol Sci. 2012;33(6):1447–1449. doi: 10.1007/s10072-011-0926-4. - DOI - PubMed

[10] Maggioni F, Bruno M, Mainardi F, Lisotto C, et al. Migraine responsive to warfarin: an update on anticoagulant possible role in migraine prophylaxis. Neurol Sci. 2012;33(6):1447–1449. doi: 10.1007/s10072-011-0926-4. - DOI - PubMed

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An unusual case report on the possible role of Warfarin in migraine prophylaxis

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An unusual case report on the possible role of Warfarin in migraine prophylaxis

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