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Comparative Study
. 1990;12(3):61-2.

[Role of intracellular pH in the development of resistance of leukemic cells to antineoplastic drugs]

[Article in Russian]
O L Shestova, T A Ogloblina, L L Litinskaia
  • PMID: 2344828
Comparative Study

[Role of intracellular pH in the development of resistance of leukemic cells to antineoplastic drugs]

[Article in Russian]
O L Shestova et al. Eksp Onkol. 1990.

Abstract

Intracellular pH (pHi) of mouse lymphoid leukemia P388 cells was measured at the wavelength of 518 and 570 nm of fluorescein: pHi of rubomycin-sensitive P388 cells was higher than pHi of the cells resistant to this antitumour antibiotic (6.98 +/- 0.04 and 6.63 +/- 0.03, respectively, P less than 0.001). The role of pHi is established during induction of the resistance of tumour cells to the antitumour drugs.

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