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. 2013 Jan 7;19(1):17-25.
doi: 10.3748/wjg.v19.i1.17.

Clinical significance of cytomegalovirus infection in patients with inflammatory bowel disease

Elena Garrido  1 , Elisa Carrera, Rebeca Manzano, Antonio Lopez-Sanroman
Affiliations

Clinical significance of cytomegalovirus infection in patients with inflammatory bowel disease

Elena Garrido et al. World J Gastroenterol. .

Abstract

Cytomegalovirus (CMV) infection is common in humans. The virus then enters a "latency phase" and can reactivate to different stimuli such as immunosuppression. The clinical significance of CMV infection in inflammatory bowel disease is different in Crohn's disease (CD) and ulcerative colitis (UC). CMV does not interfere in the clinical course of CD. However, CMV reactivation is frequent in severe or steroid-resistant UC. It is not known whether the virus exacerbates the disease or simply appears as a bystander of a severe disease. Different methods are used to diagnose CMV colitis. Diagnosis is classically based on histopathological identification of viral-infected cells or CMV antigens in biopsied tissues using haematoxylin-eosin or immunohistochemistry, other tests on blood or tissue samples are currently being investigated. Polymerase chain reaction performed in colonic mucosa has a high sensitivity and a positive result could be associated with a worse prognosis disease; further studies are needed to determine the most appropriate strategy with positive CMV-DNA in colonic mucosa. Specific endoscopic features have not been described in active UC and CMV infection. CMV colitis is usually treated with ganciclovir for several weeks, there are different opinions about whether or not to stop immunosuppressive therapy. Other antiviral drugs may be used. Multicenter controlled studies would needed to determine which subgroup of UC patients would benefit from early antiviral treatment.

Keywords: Crohn’s disease; Cytomegalovirus; Ganciclovir; Hematoxylin and eosin; Immunohistochemical; Infectious colitis; Inflammatory bowel disease; Polymerase chain reaction; Ulcerative colitis.

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References

    1. Alford CA, Stagno S, Pass RF, Britt WJ. Congenital and perinatal cytomegalovirus infections. Rev Infect Dis. 1993;12 Suppl 7:S745–S753. - PubMed
    1. Nelson MR, Erskine D, Hawkins DA, Gazzard BG. Treatment with corticosteroids--a risk factor for the development of clinical cytomegalovirus disease in AIDS. AIDS. 1993;7:375–378. - PubMed
    1. Ayre K, Warren BF, Jeffery K, Travis SP. The role of CMV in steroid-resistant ulcerative colitis: A systematic review. J Crohns Colitis. 2009;3:141–148. - PubMed
    1. Krech U. Complement-fixing antibodies against cytomegalovirus in different parts of the world. Bull World Health Organ. 1973;49:103–106. - PMC - PubMed
    1. Staras SA, Dollard SC, Radford KW, Flanders WD, Pass RF, Cannon MJ. Seroprevalence of cytomegalovirus infection in the United States, 1988-1994. Clin Infect Dis. 2006;43:1143–1151. - PubMed

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