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. 2013 Jan 15;127(2):188-96.
doi: 10.1161/CIRCULATIONAHA.112.122408.

High anthocyanin intake is associated with a reduced risk of myocardial infarction in young and middle-aged women

Aedín Cassidy  1 , Kenneth J Mukamal, Lydia Liu, Mary Franz, A Heather Eliassen, Eric B Rimm
Affiliations

High anthocyanin intake is associated with a reduced risk of myocardial infarction in young and middle-aged women

Aedín Cassidy et al. Circulation. .

Abstract

Background: Our current knowledge of modifiable risk factors to prevent myocardial infarction (MI) in young and middle-aged women is limited, and the impact of diet is largely unknown. Dietary flavonoids exert potential beneficial effects on endothelial function in short-term trials; however, the relationship between habitual intake and risk of MI in women is unknown.

Methods and results: We followed up 93 600 women 25 to 42 years of age from the Nurses' Health Study (NHS) II who were healthy at baseline (1989) to examine the relationship between anthocyanins and other flavonoids and the risk of MI. Intake of flavonoid subclasses was calculated from validated food-frequency questionnaires collected every 4 years using an updated and extended US Department of Agriculture database. During 18 years of follow-up, 405 cases of MI were reported. An inverse association between higher intake of anthocyanins and risk of MI was observed (hazard ratio, 0.68; 95% confidence interval, 0.49-0.96; P=0.03, highest versus lowest quintiles) after multivariate adjustment. The addition of intermediate conditions, including history of hypertension, did not significantly attenuate the relationship (hazard ratio, 0.70; 95% confidence interval, 0.50-0.97; P=0.03). Combined intake of 2 anthocyanin-rich foods, blueberries and strawberries, tended to be associated with a decreased risk of MI (hazard ratio, 0.66; 95% confidence interval, 0.40-1.08) in a comparison of those consuming >3 servings a week and those with lower intake. Intakes of other flavonoid subclasses were not significantly associated with MI risk.

Conclusions: A high intake of anthocyanins may reduce MI risk in predominantly young women. Intervention trials are needed to further examine the health impact of increasing intakes of commonly consumed anthocyanin-rich foods.

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Figures

Figure 1
Figure 1. Multivariate-adjusted relative risk of MI according to combined intake of strawberries and blueberries in the Nurses’ Health II Study
Model adjusted for age, physical activity, smoking, BMI, alcohol, energy, menopausal status, PMH use, aspirin use, oral contraceptive use, family history of MI, cereal fibre, saturated fatty acids, trans fatty acids, polyunsaturated fatty acids, monounsaturated fatty acids, caffeine
See this image and copyright information in PMC

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References

    1. Roger VLGA, Lloyd-Jones DM, Benjamin EJ, Berry JD, Borden WB, Bravata DM, Dai S, Ford ES, Fox CS, Fullerton HJ, Gillespie C, Hailpern SM, Heit JA, Howard VJ, Kissela BM, Kittner SJ, Lackland DT, Lichtman JH, Lisabeth LD, Makuc DM, Marcus GM, Marelli A, Matchar DB, Moy CS, Mozaffarian D, Mussolino ME, Nichol G, Paynter NP, Soliman EZ, Sorlie PD, Sotoodehnia N, Turan TN, Virani SS, Wong ND, Woo D, Turner MB on behalf of the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Executive summary: Heart disease and stroke statistics--2012 update: A report from the american heart association. Circulation. 2012;125:188–197. - PubMed
    1. WHO. Acute myocardial infarction and combined oral contraceptives: Results of an international multicentre case-control study. Lancet. 1997;349:1202–1209. - PubMed
    1. Rosenberg LKD, Helmrich SP, Miller DR, Stolley PD, Shapiro S. Myocardial infarction and cigarette smoking in women younger than 50 years of age. J Am Med Assoc. 1985;253:2965–2969. - PubMed
    1. Reynolds HRSM, Iqbal SN, Slater JN, Mancini GB, Feit F, Pena-Sing I, Axel L, Attubato MJ, Yatskar L, Kalhorn RT, Wood DA, Lobach IV, Hochman JS. Mechanisms of myocardial infarction in women without angiographically obstructive coronary artery disease. Circulation. 2011;124:1414–1425. - PMC - PubMed
    1. Ong PAA, Hill S, Vogelsberg H, Voehringer M, Sechtem U. Coronary artery spasm as a frequent cause of acute coronary syndrome: The caspar (coronary artery spasm in patients with acute coronary syndrome) study. J Am Coll Cardiol. 2008;52:523–527. - PubMed

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