doi: 10.1039/c2cc37370j.
Epub 2013 Jan 8.
Targeting cancer cells with controlled release nanocapsules based on a single aptamer
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- PMID: 23295617
- DOI: 10.1039/c2cc37370j
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Targeting cancer cells with controlled release nanocapsules based on a single aptamer
Chem Commun (Camb).
.
Abstract
Molecular gates have received considerable attention as drug delivery systems. More recently, aptamer-based gates showed great potential in overcoming major challenges associated with drug delivery by means of nanocapsules. Based on a switchable aptamer nanovalves approach, we herein report the first demonstration of an engineered single molecular gate that directs nanoparticles to cancer cells and subsequently delivers the payload in a controllable fashion.
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