Review
doi: 10.1055/s-0032-1331157.
Epub 2012 Dec 24.
Unraveling mechanisms that control platelet production
Affiliations
- PMID: 23266965
- DOI: 10.1055/s-0032-1331157
Item in Clipboard
Review
Unraveling mechanisms that control platelet production
Semin Thromb Hemost.
2013 Feb.
Abstract
Platelets are formed by giant precursor cells called megakaryocytes that reside within the bone marrow. The generation of platelets, and their release into the bloodstream by megakaryocytes, requires a complex series of remodeling events powered by the cytoskeleton to result in the release of many platelets from a single megakaryocyte. Abnormalities in this process can result in thrombocytopenia (low platelet count) and can lead to increased risk of bleeding. This review describes the process of platelet production in detail and discusses new insights into novel platelet biology.
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
Similar articles
-
The biogenesis of platelets from megakaryocyte proplatelets.J Clin Invest. 2005 Dec;115(12):3348-54. doi: 10.1172/JCI26891. J Clin Invest. 2005. PMID: 16322779 Free PMC article. Review.
-
Measurement of thrombopoietic activity through the quantification of megakaryocytes in bone marrow cytology and reticulated platelets.Res Vet Sci. 2012 Aug;93(1):313-7. doi: 10.1016/j.rvsc.2011.07.005. Epub 2011 Aug 5. Res Vet Sci. 2012. PMID: 21820687
-
Kinetics of platelets, megakaryocytes and their precursors: what to measure?Blood Cells. 1980;6(2):215-28. Blood Cells. 1980. PMID: 6991028 Review.
-
Determinants of platelet number and regulation of thrombopoiesis.Hematology Am Soc Hematol Educ Program. 2009:147-52. doi: 10.1182/asheducation-2009.1.147. Hematology Am Soc Hematol Educ Program. 2009. PMID: 20008193 Review.
-
The relationship between megakaryocyte ploidy and platelet volume in normal and thrombocytopenic C3H mice.Exp Hematol. 1990 Oct;18(9):985-9. Exp Hematol. 1990. PMID: 2397753
Cited by
-
Bad versus good cholesterol in the bone marrow.Nat Med. 2013 May;19(5):541-3. doi: 10.1038/nm.3188. Nat Med. 2013. PMID: 23652105 Free PMC article.
-
[Platelet-specific Rictor knockout inhibits platelet production and activation and reduces thrombosis in mice].Nan Fang Yi Ke Da Xue Xue Bao. 2024 Aug 20;44(8):1605-1611. doi: 10.12122/j.issn.1673-4254.2024.08.20. Nan Fang Yi Ke Da Xue Xue Bao. 2024. PMID: 39276057 Free PMC article. Chinese.
-
The RNA-binding protein SRSF3 has an essential role in megakaryocyte maturation and platelet production.Blood. 2022 Mar 3;139(9):1359-1373. doi: 10.1182/blood.2021013826. Blood. 2022. PMID: 34852174 Free PMC article.
-
Inhibition of Tropomyosin Receptor Kinase A Signaling Negatively Regulates Megakaryopoiesis and induces Thrombopoiesis.Sci Rep. 2019 Feb 26;9(1):2781. doi: 10.1038/s41598-019-39385-x. Sci Rep. 2019. PMID: 30808933 Free PMC article.
-
Platelets and cancer: a casual or causal relationship: revisited.Cancer Metastasis Rev. 2014 Mar;33(1):231-69. doi: 10.1007/s10555-014-9498-0. Cancer Metastasis Rev. 2014. PMID: 24696047 Free PMC article. Review.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
