Loaded dice for human genome mutation
- PMID: 23260131
- DOI: 10.1016/j.cell.2012.12.002
Loaded dice for human genome mutation
Abstract
Not all bases in the human genome are equally prone to chance mutations. Michaelson et al. show that individuals can acquire clusters of de novo DNA changes and propose that the likelihood of single base pair change differs across three orders of magnitude.
Copyright © 2012 Elsevier Inc. All rights reserved.
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Whole-genome sequencing in autism identifies hot spots for de novo germline mutation.Cell. 2012 Dec 21;151(7):1431-42. doi: 10.1016/j.cell.2012.11.019. Cell. 2012. PMID: 23260136 Free PMC article.
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